Conjugated Estrogens Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 17 September 2020

⏱️ 13 minutes

🔗️ Recording | iTunes | RSS

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Summary

Conjugated estrogens (Premarin) are most often used in the management of menopausal symptoms.

Estrogen therapy can increase the risk for breast cancer and the risk should be assessed before beginning therapy.

Blood clots are a potential consequence from the use of Premarin. Premarin can oppose the benefit of anticoagulation.

Conjugated estrogens are broken down by CYP3A4. Inhibitors may increase concentrations while inducers may reduce concentrations.

Transcript

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0:00.0	Hey all, welcome back to the real-life pharmacology podcast. I am your host, pharmacist Eric Christensen.
0:06.2	Thank you so much for listening today. Definitely go check us out at real-life pharmacology.com.
0:14.1	Snag your free 31-page PDF on the top 200 drugs, great little study guide.
0:20.0	And we'll send you updates as to when we have
0:22.2	new podcasts available and other educational materials. So definitely go snag that for free. And I hope
0:30.7	you enjoy today's episode. So I'm going to cover conjugated estrogens today.
0:38.3	The brand name of this medication, most commonly used medication, is Premarin.
0:44.3	And if you remember in the name of Premarin, it's kind of an interesting little quirk with the drug.
0:52.5	This drug is actually derived from pregnant horses. So pre, as a part of
1:00.7	Premarin, is meaning pregnant. Mare or Premarin, Premier is a female horse horse and N is indicative of, you know, finishing the word
1:15.3	urine. So this drug, again, comes from the urine of pregnant horses. So very kind of interesting
1:22.4	tidbit with this drug, certainly. So, you know, why would we give somebody estrogen? And there's
1:31.6	definitely several different reasons. But first, estrogen is a hormone that is heavily involved
1:39.1	in the female reproductive system. So important just to have that little piece of background
1:46.0	as it might be indicative of what we're trying to treat or manage.
1:51.2	So those indications.
1:53.2	If you have any type of disorder where a patient is not producing estrogen
1:59.4	or not fully producing estrogen.
2:03.3	That's a situation where we could potentially supplement with estrogen.
2:09.0	There are certain types of cancers that we may use estrogen for.
2:14.8	Another situation may be abnormal bleeding, for example. So these are generally more
2:21.1	rare circumstances, and I can't say in clinical practice that I see them a lot. By far, the most
	...

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