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Armchair Expert with Dax Shepard

Colleen Cutcliffe (on the microbiome)

Armchair Expert with Dax Shepard

Armchair Umbrella

Tv & Film, Comedy, Music

4.669.9K Ratings

🗓️ 18 February 2026

⏱️ 124 minutes

🧾️ Download transcript

Summary

Colleen Cutcliffe (Pendulum Therapeutics) is a doctor of biochemistry and microbiology and CEO and co-founder of Pendulum Therapeutics. Colleen joins the Armchair Expert to discuss starting a microbiome supplement company inspired by her premature daughter who had to take antibiotics, applying hyenas' evolved ability to digest rotting meat to study gut bacteria, and how fecal transplants reliably help treat C. diff. Colleen and Dax talk about the real linkages between microbiome and depression, obesity, and more, how the body’s natural GLP1s function, and why a healthy gut is a resilient gut. Colleen explains her wooden fence analogy to illustrate leaky guy syndrome, remarkable results from experiments giving mice Akkermansia, and that the beauty of the microbiome is that everything is recoverable.

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Transcript

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0:00.0

Welcome, welcome, welcome to armchair expert, experts on expert.

0:04.2

I'm Dax Shepherd.

0:05.1

I'm joined by Monica Padman.

0:06.3

Hi.

0:07.1

Long time coming, we really are interested in this.

0:10.3

For people who've been listening to the show for years, there was a period six years ago

0:14.1

where we were obsessed with getting a fecal transplant from our friend Amy.

0:17.5

Yep.

0:18.2

And it took us six years to get someone who actually knows about this space.

0:23.3

And her name is Colleen Cutcliffe, and she is a microbiome scientist and health advisory board member for Johns Hopkins Bloomberg School of Public Health.

0:33.6

Very prestigious school, the one you don't like to say because there's an S at the end of John.

0:38.7

Plural and plural.

0:39.8

There was something funny on the internet.

0:41.6

I forget exactly what it was, but it was like people have trouble with pronouns, but they're able to say Ruth's Chris.

0:46.9

That's hard for me too.

0:48.2

It's hard.

0:49.3

Yeah, it's two essay.

0:51.6

Yeah.

0:51.9

At any rate, very prestigious, as we know.

0:55.2

And she has a company, you'll hear about it, called Pendulum, that is making probiotics and prebiotics and with a much different degree of oversight.

1:07.5

Yeah, like, does Ruth own Chris?

1:10.3

Right.

...

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