meta_pixel
Tapesearch Logo
Log in
The Carlat Psychiatry Podcast

Cobenfy: A New Antipsychotic

The Carlat Psychiatry Podcast

Pocket Psychiatry: A Carlat Podcast

Health & Fitness, Mental Health, Medicine, Alternative Health

4.8440 Ratings

🗓️ 7 October 2024

⏱️ 12 minutes

🧾️ Download transcript

Summary

KarXT (Cobenfy) is the first antipsychotic that doesn’t block dopamine. We trace the origins of this new drug to a South Asian herb used for over 5,000 years, up to the three EMERGENT trials that led to its FDA approval.CME: Take the CME Post-Test for this Episode (https://www.thecarlatreport.com/blogs/2-the-carlat-psychiatry-podcast/post/4842-cobenfy-a-new-antipsychotic)Published On: 10/07/2024Duration: 12 minutes, 28 secondsChris Aiken and Kellie Newsome, PMHNP have disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Transcript

Click on a timestamp to play from that location

0:00.0

Last week, the FDA approved Cabenfi, the first antipsychotic to make a clean break with the usual dopamine blocking mechanism of action.

0:09.3

But its origins go way back to the beetle leaf, an herbal stimulant used in Asia for over 5,000 years.

0:20.1

Welcome to the Carlet Psychiatry Podcast, keeping psychiatry honest since 2003. I'm Chris Aiken, the editor-in-chief of the Carlatte Psychiatry Podcast, keeping psychiatry honest since 2003.

0:25.8

I'm Chris Aiken, the editor-in-chief of the Carlatte Psychiatry Report.

0:29.7

And I'm Kelly Newsom, a psychiatric NPR, and a dedicated reader of every issue.

0:36.9

Every September, I give a talk on the top research updates of the past year at the North Carolina Psychiatric Association's annual meeting.

0:45.5

This year, I did not give the talk. As the conference opened in Asheville, North Carolina,

0:51.3

we heard a loud crash over our heads. Part of the Renaissance Hotel had fallen on the flat roof

0:57.9

above our heads. The lights went out, the windows moved in the wind and rain, but the group

1:04.0

pulled together, setting up

1:05.9

flashlights in the pitch-dark auditorium as Dr. Mahulman-Kod continued his seminar. We didn't know

1:13.8

where all this was headed, but we all figured if things got worse, we could all drive home. We

1:20.1

were wrong. Within a few hours, every road out of Asheville was closed. There was no phone or

1:26.5

internet. News came in by word of mouth. Food, water, and gasoline were all in short supply,

1:34.4

as only a few restaurants stayed open and the ones that did quickly ran out of supplies.

1:40.3

Sixty miles away, the Nalachaki River flooded into a Tennessee hospital that sat on its banks,

1:47.2

forcing patients and staff onto its roof where three Black Hawk helicopters lifted them to safety.

1:54.8

My main fear during all of this was of riots, but I was wrong.

2:00.1

People didn't act worse under this duress.

2:03.3

They were more friendly and helpful as they waited in two-hour-long lines to buy a box of crackers.

2:09.5

Neighbors went house-to-house to check on each other and offer support.

2:14.0

The cause of all this chaos was Hurricane Helene, which brought similar damage from Florida to Indiana last week,

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from Pocket Psychiatry: A Carlat Podcast, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Pocket Psychiatry: A Carlat Podcast and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2025.