Cobenfy: A New Antipsychotic
The Carlat Psychiatry Podcast
The Carlat Psychiatry Podcast
4.7 • 524 Ratings
🗓️ 7 October 2024
⏱️ 12 minutes
🧾️ Download transcript
Summary
KarXT (Cobenfy) is the first antipsychotic that doesn’t block dopamine. We trace the origins of this new drug to a South Asian herb used for over 5,000 years, up to the three EMERGENT trials that led to its FDA approval.
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Published On: 10/07/2024
Duration: 12 minutes, 28 seconds
Chris Aiken and Kellie Newsome, PMHNP have disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.
Transcript
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| 0:00.0 | Last week, the FDA approved Cabenfi, the first antipsychotic to make a clean break with the usual dopamine blocking mechanism of action. |
| 0:09.3 | But its origins go way back to the beetle leaf, an herbal stimulant used in Asia for over 5,000 years. |
| 0:20.1 | Welcome to the Carlet Psychiatry Podcast, keeping psychiatry honest since 2003. I'm Chris Aiken, the editor-in-chief of the Carlatte Psychiatry Podcast, keeping psychiatry honest since 2003. |
| 0:25.8 | I'm Chris Aiken, the editor-in-chief of the Carlatte Psychiatry Report. |
| 0:29.7 | And I'm Kelly Newsom, a psychiatric NPR, and a dedicated reader of every issue. |
| 0:36.9 | Every September, I give a talk on the top research updates of the past year at the North Carolina Psychiatric Association's annual meeting. |
| 0:45.5 | This year, I did not give the talk. As the conference opened in Asheville, North Carolina, |
| 0:51.3 | we heard a loud crash over our heads. Part of the Renaissance Hotel had fallen on the flat roof |
| 0:57.9 | above our heads. The lights went out, the windows moved in the wind and rain, but the group |
| 1:04.0 | pulled together, setting up |
| 1:05.9 | flashlights in the pitch-dark auditorium as Dr. Mahulman-Kod continued his seminar. We didn't know |
| 1:13.8 | where all this was headed, but we all figured if things got worse, we could all drive home. We |
| 1:20.1 | were wrong. Within a few hours, every road out of Asheville was closed. There was no phone or |
| 1:26.5 | internet. News came in by word of mouth. Food, water, and gasoline were all in short supply, |
| 1:34.4 | as only a few restaurants stayed open and the ones that did quickly ran out of supplies. |
| 1:40.3 | Sixty miles away, the Nalachaki River flooded into a Tennessee hospital that sat on its banks, |
| 1:47.2 | forcing patients and staff onto its roof where three Black Hawk helicopters lifted them to safety. |
| 1:54.8 | My main fear during all of this was of riots, but I was wrong. |
| 2:00.1 | People didn't act worse under this duress. |
| 2:03.3 | They were more friendly and helpful as they waited in two-hour-long lines to buy a box of crackers. |
| 2:09.5 | Neighbors went house-to-house to check on each other and offer support. |
| 2:14.0 | The cause of all this chaos was Hurricane Helene, which brought similar damage from Florida to Indiana last week, |
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