Clopidogrel Pharmacology
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist
4.9 • 773 Ratings
🗓️ 4 July 2019
⏱️ 14 minutes
🧾️ Download transcript
Summary
Clopidogrel is an antiplatelet agent that is often used in combination with aspirin to help reduce the risk of an MI.
The risk of bleed is a high priority with the use of clopidogrel. Patients must be monitored for signs and symptoms of bleeding and bruising.
Clopidogrel is a prodrug that is converted to its active metabolite by CYP2C19.
Fluconazole can inhibit CYP2C19 which may reduce the effectiveness of clopidogrel.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
Transcript
Click on a timestamp to play from that location
| 0:00.0 | Hey all, Eric Christensen, pharmacist back here with the Real Life Pharmacology podcast. |
| 0:06.0 | Today I'm going to cover Clipidogrel. |
| 0:09.0 | Brand name of that medication is Plavix. |
| 0:12.0 | And this is classified as an anti-platelet agent. |
| 0:16.0 | In practice, this medication is definitely used on a relatively frequent basis. |
| 0:23.7 | One really important thing that comes to mind within the drug's mechanism of action, |
| 0:30.5 | and I'll talk a little bit more about this too as we get into drug interactions, |
| 0:35.9 | but clopidigril is what's called a pro-drug. |
| 0:38.9 | And that means that the drug is given, and the active ingredient, the active component |
| 0:45.0 | within that medication is not actually active right away. |
| 0:52.1 | So what happens is the drug is absorbed and the drug is converted into |
| 0:59.0 | by the body into the active form that actually has the physiological anti-platelet type effects. |
| 1:09.0 | So that's what a pro drug is, basically a drug that needs to be converted by the body into its |
| 1:16.3 | active form. |
| 1:18.9 | So again, I'll talk a little bit more about this in some of the warnings and adverse effects |
| 1:24.7 | as well as potentially touch on drug interactions as well. |
| 1:29.2 | So when we think about classifications and anti-platlet agents, |
| 1:33.5 | you've got to remember what we're trying to do with these medications, |
| 1:37.4 | and it's virtually always trying to prevent platelets from aggregating together and ultimately prevent |
| 1:48.0 | blood clots and things of that nature, where we stop the blood flow. |
| 1:55.0 | And two of the most important situations are in the heart where we can have a myocardial infarction where |
| 2:03.5 | basically blood flow is at least limited and potentially even totally blocked. We've also got the |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2026.

