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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Clopidogrel Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 4 July 2019

⏱️ 14 minutes

🧾️ Download transcript

Summary

Clopidogrel is an antiplatelet agent that is often used in combination with aspirin to help reduce the risk of an MI.



The risk of bleed is a high priority with the use of clopidogrel. Patients must be monitored for signs and symptoms of bleeding and bruising.



Clopidogrel is a prodrug that is converted to its active metabolite by CYP2C19.



Fluconazole can inhibit CYP2C19 which may reduce the effectiveness of clopidogrel.

Transcript

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0:00.0

Hey all, Eric Christensen, pharmacist back here with the Real Life Pharmacology podcast.

0:06.0

Today I'm going to cover Clipidogrel.

0:09.0

Brand name of that medication is Plavix.

0:12.0

And this is classified as an anti-platelet agent.

0:16.0

In practice, this medication is definitely used on a relatively frequent basis.

0:23.7

One really important thing that comes to mind within the drug's mechanism of action,

0:30.5

and I'll talk a little bit more about this too as we get into drug interactions,

0:35.9

but clopidigril is what's called a pro-drug.

0:38.9

And that means that the drug is given, and the active ingredient, the active component

0:45.0

within that medication is not actually active right away.

0:52.1

So what happens is the drug is absorbed and the drug is converted into

0:59.0

by the body into the active form that actually has the physiological anti-platelet type effects.

1:09.0

So that's what a pro drug is, basically a drug that needs to be converted by the body into its

1:16.3

active form.

1:18.9

So again, I'll talk a little bit more about this in some of the warnings and adverse effects

1:24.7

as well as potentially touch on drug interactions as well.

1:29.2

So when we think about classifications and anti-platlet agents,

1:33.5

you've got to remember what we're trying to do with these medications,

1:37.4

and it's virtually always trying to prevent platelets from aggregating together and ultimately prevent

1:48.0

blood clots and things of that nature, where we stop the blood flow.

1:55.0

And two of the most important situations are in the heart where we can have a myocardial infarction where

2:03.5

basically blood flow is at least limited and potentially even totally blocked. We've also got the

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