Circadian Rhythms: How Are They Connected To Psychiatric Disorders?
Finding Genius Podcast
Richard Jacobs
4.4 • 1K Ratings
🗓️ 21 March 2023
⏱️ 39 minutes
🧾️ Download transcript
Summary
In this episode, we sit down with Dr. Colleen A. McClung, a Professor of Psychiatry and Clinical and Translational Science at the University of Pittsburgh. She is also the Director of the NIDA-funded Center for Adolescent Reward, Rhythms, and Sleep – a translational center dedicated to understanding the contribution of sleep and circadian disruptions to addiction vulnerability in adolescents.
As a renowned leader in her field, Dr. McClung focuses her research on the molecular mechanisms of bipolar disorder, major depression, and drug addiction. By studying the interconnectivity between these psychiatric disorders and the circadian clock, Dr. McClung has made many fascinating discoveries – some you may never have guessed…
Join in now to find out:
- What the body's "molecular clock" is made up of.
- The two major processes that control sleep.
- What happens to your brain when you fall asleep.
- Factors that can negatively affect your circadian rhythm.
To learn more about Dr. McClung and her research, click here now!
Episode also available on Apple Podcasts: http://apple.co/30PvU9C
Transcript
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| 0:00.0 | I'm really a mechanistic scientist. |
| 0:02.1 | You know, I really want to understand |
| 0:03.9 | the biological basis of these disorders. |
| 0:06.2 | And so we're really studying that in that molecular clock, |
| 0:10.1 | which is in every single cell, |
| 0:11.7 | pretty much of the entire brain, the entire body. |
| 0:14.9 | These are, it's made up of genes |
| 0:17.3 | and that basically they're called transcription factors |
| 0:21.6 | and they control the expression of other genes. |
| 0:24.7 | And it just so happens that these particular genes |
| 0:28.5 | will cycle over the course of 24 hours in their, |
| 0:32.2 | their function. |
| 0:33.6 | And that leads to the expression of a whole bunch |
| 0:36.9 | of other genes that have a 24 hour rhythm. |
| 0:40.0 | So that's how rhythms are controlled in the cell. |
| 0:44.5 | Forget frequently asked questions. |
| 0:46.3 | Common sense, common knowledge, or Google. |
| 0:48.8 | How about advice from a real genius? |
| 0:51.1 | 95% of people in any profession |
| 0:53.4 | are good enough to be qualified in license. |
| 0:55.3 | 5% call above and beyond. |
| 0:57.2 | They become very good at what they do. |
... |
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