Circadian Medicine: The Future of Fat Loss, Metabolic Health and Medicine
High Intensity Health with Mike Mutzel, MS
Mike Mutzel
4.7 • 1.3K Ratings
🗓️ 17 May 2022
⏱️ 34 minutes
🧾️ Download transcript
Summary
Circadian rhythm optimization can improve metabolic health and support longevity. Learn ways to match lifestyle interventions with your circadian clock.
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Link to show notes and video: https://bit.ly/3a6Zo9D
Time Stamps:
02:10 A dysregulated circadian clock system causes disease and dysfunction at the cellular level.
02:30 20%-50% of your protein synthesizing genes oscillate on a diurnal rhythm.
03:40 Disease alters the circadian clock system.
04:40 Blood sugar management supplements and pharmaceuticals would be best taken in the afternoon or evening, when blood sugar levels are most erratic.
05:03 Blood lipid level management supplements and pharmaceuticals would be best taken in the evening, when lipid synthesis occurs.
05:54 Decrease inflammatory tone before you go to sleep by doing some light yoga, breath work, take probiotics or curcuminoids.
07:30 Sleep perturbations cause dysbiosis in gut bacteria.
09:40 The intensity of your circadian rhythm is reduced as you age.
11:10 Circadian chronotypes influence the timing of cancer interventions.
12:00 N-acetylcysteine and other antioxidants are best taken in the evening or before bed.
12:40 Results of studies may be inaccurate due to timing.
15:20 Shift workers have a higher incidence of cancer, metabolic disease, and obesity.
14:50 Cold, food, heat, meal timing and exercise influence your circadian clock system.
17:20 Menopause challenges the circadian clock system, reducing the amplitude of the rhythms.
18:40 Young people/children’s circadian rhythm is more light sensitive. Artificial light can be more problematic.
23:00 Fasting and feeding influence your circadian clock system. Break your fast between 11 and 1 pm when your digestive system is primed.
24:45 DHEA antagonizes cortisol’s synthesis and expression.
28:05 Darkness is a circadian cue. Exercise light hygiene.
31:25 Morning cold exposure and evening heat exposure enhances circadian amplitude.
Transcript
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| 0:00.0 | In today's show, we're going to take a deeper dive into meal timing, exercise timing, |
| 0:03.5 | feeding fasting when the compression and timing of your nutrients, that is dietary supplements, |
| 0:08.6 | so as to maximize circadian rhythm health and optimization. I came across this fascinating, |
| 0:14.0 | really deep exploration into this whole field of circadian medicine. So this is a term that |
| 0:20.4 | is actually being thrown around jargon, you know, by scientists and researchers. And I want to |
| 0:25.3 | just break down this sort of complex paper here and share with you some images that I came across |
| 0:29.9 | that help me better understand this information so that I'm working one-on-one with clients |
| 0:34.2 | who have sleep issues, who have hormone dysfunction, who have chronic autoimmune issues, allergies, |
| 0:40.3 | asthma, atopy, things like that, where we can really optimize the timing of different dietary |
| 0:46.0 | supplements, other interventions such as fasting, meals, exercise, and even light exposure. |
| 0:51.7 | Even we're going to talk about temperature exposure because your corbide temperature fluctuates |
| 0:56.7 | on a diurnal rhythm throughout the day. So we're going to talk about all these things with the bigger |
| 1:01.4 | bigger context of optimizing circadian rhythm health and function. And again, as this paper talks |
| 1:06.7 | about, the foundations of circadian medicine. Now this is really important, but unfortunately, |
| 1:12.4 | and again, this paper makes the case. And I'm going to say this, hopefully not too many times, |
| 1:16.7 | but a few times for the purposes of indelibly inkiness into your mind, that we really need to |
| 1:23.6 | approach any ailment or dis-ease that we are dealing with, whether it's high blood pressure, |
| 1:28.3 | whether it's cardiovascular risk factors, whether it's optimizing the immune system response to |
| 1:33.4 | a COVID-19 vaccination, which is I'm going to share with you some new research that it's actually |
| 1:37.4 | looking at. There's looking at people's sleep habits and their chronotype to see if there's |
| 1:43.6 | a sort of commensurate association with the immunologic response after an immunization. |
| 1:48.5 | It is not quite interesting because we know that shift workers and people that are working in high |
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