You know both of my guests today, I'm sure, by their bodies of work.

Actresses Christina Applegate and Jamie Lynn Sigler have a combined nearly 90 years in the industry.

Iconic roles on shows like married with children and the Sopranos,

turning both Christina and Jamie Lynn into household names. But today, the actresses are also known

for a very different role. Christina and Jamie Lynn are public faces of multiple sclerosis,

the harrowing disease that they are both living with. Jamie Lynn was diagnosed in 2003 at

the age of just 20, and Christina at age 49, not even four years ago. And while in two very different

places with MS, Christina and Jamie Lynn have found tremendous support in one another. Jamie Lynn will

tell you, Christina opened her up

after years of suffering quietly. She's now done trying to appear to be perfect. And Christina

is leaning on Jamie Lynn to share the complexities of the disease. Only someone else living with it

would understand. Their journey together is one of pain and triumph,

but there's also so much beauty in the bond that connects them. I hope you'll listen to today's

episode, not just with empathy, but also with curiosity. These are two women with a truly unique

perspective on life. I found both Christina and Jamie Lynn to be fascinating, insightful,

and powerful, and I hope you will too. I'm Hoda Kotb. Welcome to my podcast, Making Space.

All right, guys.

First of all, I just want to tell you how happy I am to be sitting with you, too.

I kind of feel like I know you.

I've watched some dear friends of mine interview you, and I love your friendship.

There are a million things that connect you, but I don't even care at this moment what those things are because I love your friendship. There are a million things that connect you,

but I don't even care at this moment what those things are because I love your friendship.

...