Christian McCaffrey faces former Panthers team in Week 12 matchup

49ers Talk: A San Francisco 49ers Podcast

NBC Sports Bay Area

Nfl, Football, Matt Maiocco, San Francisco 49ers, Sports

4.6 • 988 Ratings

🗓️ 21 November 2025

⏱️ 52 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan reflect on the blockbuster trade that brought Christian McCaffrey to San Francisco ahead of Monday night's matchup against his former team. Additionally, Matt and Jennifer discuss how a healthy 49ers offense will improve their run game. Matt then sits down with defensive back Deommodore Lenoir to discuss his growth as a leader and team captain of the 49ers’ defense.

Transcript

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0:00.0	The clock is ticking. Are they all ready? Yep, already. Excellent. Now through December 7th, buy three, get one free on four select in-stock tires. Sam, the customers are ready. Are you? All ready! Only at Big O Tires.
0:16.9	The last time the 49ers and the Carolina Panthers got together, it changed the paths of both franchises.
0:28.5	It was 11 days after the teams met in week five of the 2022 season that 49ers general manager, John Lynch, worked out a trade to acquire the Panthers best player.
0:38.3	And that player, Christian McCaffrey, has been an indispensable member of the 49ers ever since.
0:44.4	McCaffrey will go up against his former team for the first time since that trade three years ago.
0:49.4	The 49ers and Panthers meet on Monday night football in a key matchup involving two teams in the thick of the NFC playoff hunt.
0:57.3	Brock Purdy made it out of his week 11 return just fine, and he will lead a 49ers offense that is in its best shape all season.
1:05.4	Jennifer Lee Chan and I will bring you up to date on the 49ers as they see if they can string together back-to-back wins.
1:12.0	We'll also hear from 49ers cornerback, Geomador-Linor,
1:15.0	who could be facing a big matchup against one of the NFL's top rookies.
1:19.7	We'll have all that and much more on this episode of 49ers talk coming at you right now.
1:25.5	Welcome to another episode of 49ers talk on NBC Sports Bay Area.com.
1:31.7	Introducing your hosts, Matt Mayoko and Jennifer Lee Chan.
1:36.4	All right, this is 49ers talk, brought you by Bigotires.
1:39.7	This is the perfect time to give your car, truck, or SUV the TLC it needs.
1:45.2	Set an appointment at bigotires.com and drive away knowing you got the best deal on the road with the team you trust Big O tires.
1:53.2	All right, I'm Matt.
1:54.4	She's Jennifer, and it is Monday night football.
1:57.4	This is the first, what I consider the first real prim prime time game. Right. They play that Thursday night game.
2:03.4	Right. And that doesn't even really go to the full nation because you have to have certain streaming platforms.
2:08.7	Yeah. Yeah. So this one, I got to admit, Jennifer, when I saw it when the schedule came out, I saw 49ers and Panthers, Monday night football.
2:17.9	I remember your reaction.
	...

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