Brock Purdy's return ignites Christian McCaffrey, George Kittle as 49ers thrash Cardinals

49ers Talk: A San Francisco 49ers Podcast

NBC Sports Bay Area

Nfl, Football, Matt Maiocco, San Francisco 49ers, Sports

4.6 • 988 Ratings

🗓️ 17 November 2025

⏱️ 39 minutes

🔗️ Recording | iTunes | RSS

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Summary

Brock Purdy's return sparked the 49ers' offense, it also brought a much needed divisional win in a blowout against the Cardinals. Purdy threw for three touchdowns on Sunday, two of which went to a favorite target in tight end George Kittle and the other went to offensive fulcrum Christian McCaffrey, who leads the NFL in scrimmage yards this season through Week 11. Skyy Moore set the tone, returning the opening kickoff 98 yards to the 1-yard line, setting up a McCaffrey 1-yard touchdown run. San Francisco maintained control throughout the game, one in which Arizona did itself no favors accumulating a franchise-record 17 penalties. San Francisco did not escape Arizona unscathed though, as kicker Eddy Piñeiro suffered a hamstring injury in the third quarter that could force the team to bring in a new kicker. On this episode of '49ers Talk,' co-hosts Matt Maiocco and Jennifer Lee Chan break down San Francisco's outstanding performance against the Cardinals Sunday at State Farm Stadium. Matt and Jennifer discuss the impact of Purdy's return on the 49ers' offense during a crucial stretch, Kittle and CMC's dominance, and how injuries to both Piñeiro and linebacker Tatum Bethune might affect the team ahead of Monday's showdown with the Carolina Panthers.

Transcript

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0:00.0	The clock is ticking. Are they all ready? Yep, already. Excellent. Now through December 7th, buy three, get one free on four select in-stock tires. Sam, the customers are ready. Are you? All ready! Only at Big O Tires.
0:20.2	Brock Purdy made his return to the 49ers starting lineup on Sunday in his home state of Arizona.
0:26.1	And in the words of Christian McCaffrey, he was simply vintage Brock Purdy.
0:31.6	The 49ers jumped on the Arizona Cardinals early and did not allow the last place team in the NFC West to ever come up for error.
0:39.4	The result was a decisive victory that improves the 49ers to 7 and 4 on the season to keep pace
0:45.3	with the other contenders in the NFC.
0:48.3	Jennifer Lee Chan was in Arizona and she'll update us on what she observed, including
0:52.9	a couple of potential injury problems to monitor.
0:56.7	McCaffrey and George Kittle were also at the tops of their games, and while the 49ers defense was far from perfect,
1:03.3	Robert Salas' unit came up with three big takeaways. We'll have all that and much more on this episode of 49ers talk
1:09.9	coming at you right now. Welcome to this episode of 49ers talk coming at you right now.
1:12.4	Welcome to another episode of 49ers talk on NBC Sports Bay Area.com.
1:18.5	Introducing your hosts, Matt Mayoko and Jennifer Lee Chan.
1:23.1	All right, this is 49ers talk brought you by Bigotire.
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1:28.9	Set an appointment at bigotires.com and drive away knowing you got the best deal on the road at Bigo, the team you trust.
1:37.1	All right, Jennifer.
1:38.3	I'm not sure what to make of this game.
1:40.9	49ers, they took care of business.
1:43.4	The return of Brock Purdy, the offense looked good.
1:46.5	The defense was prolific in both ways, both with the turnovers or the takeaways, but also allowing
1:56.6	Jacoby Brissette to have a historical day.
	...

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