Ch-Ch-Ch-Ch-Changes (Turn and Face the Strains): SARS-CoV-2 Mutations

Unbiased Science

@unbiasedscipod

Education, Science, Health & Fitness

4.4 • 644 Ratings

🗓️ 8 February 2021

⏱️ 38 minutes

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Summary

On this week's episode we discuss mutations, specifically in the context of SARS-CoV-2. We set the stage by describing what a mutation is and how this random process occurs in all organisms. We discuss the emergence of SARS-CoV-2 and a primer on zoonotic diseases before focusing on mutation rates of SARS-CoV-2, and comparison to another RNA virus, influenza virus. We talk about the key mutations of the variants of concern B.1.1.7, B.1.351, and P.1 and the spike antigen of the virus, and why these mutations have become more prevalent. We wrap up with a discussion on the implications of vaccine efficacy in light of these new variants, and underscore the need for rapid vaccination globally. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance.

Transcript

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0:26.8	Get the new Tony Hawk's Pro Skater 3 and 4 and show the world that the shred's not dead.
0:31.4	Get Tony Hawk's Pro Skater 3 and 4 available now.
0:35.4	Yeah, oh, I am a scientist. Yeah, oh, I am a scientist. Now. Welcome to now.
0:46.8	We've got to live on science alone.
0:50.6	Welcome to unbiased science, where we bring scientific method to the madness.
0:57.5	We're your hosts, Dr. Jessica Steyer and Dr. Andrea Love.
1:01.8	And today is a real treat because we get to pick Dr. Love's brain on all things related to mutations because we have received so many questions about this.
1:15.4	Before we dive into that, let's check in, Andrea, and give a little update on what we're
1:22.3	working on these days. So what are you up to? You've been very busy. I've been very busy. You know, so I work for a
1:30.3	biotech company, so we're often juggling a lot of different things. I would say the two,
1:35.8	the two project areas that I've been working on most these days are COVID research, you know,
1:43.8	so specifically virology, vaccine screening and antiviral
1:48.4	screens, and then cancer immunotherapy.
	...

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