Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Derek Christensen.

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All right, let's get into the drug of the day today, and that is cephalaxin.

Brand name of this medication is Keflex, and this is a cephalosporin, as you could probably imply,

from the Ceph beginning of the word there. And it is a first-generation

cephalosporin. So if you remember previously had done Cephriaxone, and as we get to higher

generations, we generally get more and more gram-negative coverage. So Keflex and

being a first-generation cephalosporne, we are going to primarily have gram-positive coverage,

and gram-positive bugs include strep and staff species. Those are the most common targets that we're going to use a drug like Cephylaxen for.

With that said, there is potentially some activity against sensitive,

certain E. coli species, Klebsiella species, proteus species.

And as we get to talking about indications, urinary tract infection is sometimes an

indication for cephalaxon.

Generally not a first-line agent, but if we have susceptible species, we possibly can use cephalaxin in certain situations.

Now, most commonly where you're going to see cephalaxin used is skin and soft tissue infections.

Now, these are often staff or strep type infections,

which Keflex certainly will cover there. Other potential infections that may have,

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