Hey, all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen.

Thank you so much for listening today. As always, go check out Real Life Pharmacology.com.

If you subscribe to our mailing list, we've got a free 31-page PDF on the top 200 drugs.

I get great comments on that resource. It's just an awesome, awesome resource

if you're going through pharmacology classes, board exams, just a great refresher on some of the

most important clinical things with the top 200 drugs. So you can get that absolutely for free.

Simply an email will get you there. All right, the drug of the day today is

Cephtriaxone. Brand name of this medication is rosephine. Classification, obviously, it's an

antibiotic. And with the Ceph beginning of the word there, obviously this is going to be a cephalosporin.

Now remember, there's bunch of different generations of cephalosporin.

So there's first through the fifth now.

And what you've got to remember is as you get to higher numbers,

we get more and more coverage generally.

Okay, that's a generality.

Individual agents can vary from drug to drug.

But as you get to further generations, you generally tend to get more coverage.

With that said, Cephtriaxone is a third generation Cephalosporan, and it is definitely a workhorse. You see this one used a lot

in hospital type settings mostly because it's not an oral agent. It's IM or IV. Mechanistically,

how do these drugs work? Well, if you've memorized, you know, the mechanism of action for penicillin antibiotics, other cephalosporins,

these drugs, or Cephtraxone specifically, binds to penicillin binding proteins,

which prevents peptidoglycan synthesis.

And if you remember that synthesis is critical for formation of bacterial

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