Hey all, welcome back to the Real Life Pharmacology podcast. I am your host, Eric Christensen.

And you can certainly reach out to us at real life pharmacology.com. Also, you can track me down on LinkedIn as well.

So getting into the podcast today, let's cover cellicoxib.

So this medication is classified as a Cox2 inhibitor.

And essentially, it's going to have similar clinical effects to traditional insides.

So I think that's a good place to start.

Now if you remember Cox 1 and Cox 2,

Cox 2 is thought of as an enzyme that mediates

prostate glandins that regulate pain, fever, and inflammation.

Cox 1, that can be a little bit more of the anti-platelet type activity

and things of that nature.

So mechanistically, how this drug works is it inhibits cyclooxygenase 2 or Cox 2 that reduces those prostaglandins by inhibiting that enzyme.

And those, again, those prostaglandins are responsible for pain and fever and inflammation.

And so by inhibiting those, reducing the amount of prostate glandants,

we essentially reduce pain and inflammation,

which flows into what this medication is used for,

and that's various pain syndromes.

Generally, we, you know, reserve the insides and cox twos for more inflammatory type pain,

but they certainly can be used for like osteoarthritis and things of that nature too.

Adverse effect profile, so there is GI risk with cellicoxib.

Now, it's likely less than a drug like endomethcin or ibuprofen, traditional neds,

but the risk still is there.

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