Tonight, the hope on the horizon after a big medical announcement, just as the president-elect's

coronavirus advisor warns, America is headed for COVID hell.

As the U.S. hits 10 million infections, Pfizer says its vaccine is more than 90% effective.

Is this the game changer the world has been waiting for? And how soon will

Americans be able to get it? Plus, President-elect Joe Biden with an urgent plea.

Please, I implore you. Wear a mask. Stock market surge. The vaccine breakthrough sends the Dow

soaring. As cases rise in every part of the

country, leading grocery store chains put new limits on how much toilet paper you can buy.

Another White House outbreak was President Trump's election night party a super spreader event. That's

the question tonight after his chief of staff, Dr. Ben Carson,

and other top aides test positive for coronavirus. Not conceding. President Trump has his fourth

straight day without public events as Republicans back his election legal battle. Pentagon purge. The president terminates Defense Secretary Mark Esper.

What other members of the administration could be next.

Tropical storm Ada.

Dangerous flooding from more than a foot of rain in South Florida.

Tonight, the storm's uncertain path, and could it strengthen to a hurricane before

hitting Florida again. And what is an icon? Remembering TV legend Alex Trebek?

We have hidden somewhere on the board a daily double. The man who made a game show,

Appointment Television. This is the CBS TV. man who made a game show appointment television.

This is the CBS Evening News with Nora O'Donnell, reporting from the nation's capital.

Good evening and thank you for joining us.

We're going to begin tonight with a possible breakthrough in the development of a coronavirus vaccine, just as the country is entering a dangerous and deadly new phase of the pandemic.

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