Canagliflozin Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 26 May 2022

⏱️ 14 minutes

🔗️ Recording | iTunes | RSS

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Summary

Canagliflozin is an SGLT2 inhibitor. I discuss the pharmacology, dosing, adverse effects, and drug interactions of this medication.

Canagliflozin reduces blood sugar, by facilitating its exit through the urine. This can increase the risk of genitourinary infections.

A diuresis type effect can happen due to canagliflozin and this effect may be exacerbated by the use of thiazide and loop diuretics.

Hyperkalemia has been reported with the use of canagliflozin; the risk for this is increased with the use of medications like ACE inhibitors, ARBs, and aldosterone antagonists.

Transcript

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0:00.0	Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host pharmacist, Eric Christensen.
0:05.3	Thank you so much for listening. As always go to real life pharmacology.com. Get your free 31-page
0:11.6	PDF on the top 200 drugs. Great study guide, great review. If you're a nurse practitioner,
0:18.4	med, student, pharmacist, lots of good info in there, and I pulled out that
0:24.2	info based upon what I actually see in clinical practice as well as things I've definitely
0:29.3	encountered on board exams.
0:31.7	So definitely something to have to your virtual library there.
0:37.1	So simply an email.
0:38.5	We'll get you access to that.
0:39.7	You can do that at real-life pharmacology.com.
0:43.3	Drug of the day today is canna glyphlozen.
0:47.2	Brand name is Invokana.
0:50.1	This is an SGLT2 inhibitor.
0:53.0	I've covered a couple of them already, I believe.
0:56.2	This one is less frequently used than some of the other ones, like Dapaglyphlozen, for example.
1:04.9	So knowing this is an SGLT2 inhibitor, hopefully you recall from maybe those previous podcasts. This drug is primarily
1:13.2	going to be used for diabetes and obviously lowering blood sugar. The SGLT2, remember, that
1:23.9	stands for sodium glucose co-transporter 2, and this drug inhibits that
1:29.8	transporter, which ultimately, from a mechanism standpoint, basically kicks glucose out of the
1:37.5	body through the urine when we use this medication.
1:42.1	So dosing, there's two dosages, 100 and 300 milligrams.
1:46.0	You can increase up to 300 after four weeks.
	...

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