Caffeine, Tolerance, and Getting Your Pre-Workout to Work Again with Dr. Eric Trexler
RP Strength Podcast
Dr. Mike Israetel, Nick Shaw
4.7 • 582 Ratings
🗓️ 30 March 2026
⏱️ 54 minutes
🧾️ Download transcript
Summary
Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition.
Dr. Eric Trexler's Links:
- RP article: Caffeine, The Double-Edged Sword
- Stronger by Science: The Lifter's Guide to Caffeine
- Instagram: @trexlerfitness
- ResearchGate: Eric Trexler publications
- Twitter/X: @EricTrexler
Timestamps:
00:00 Eric and Nick's BEEF 🥩
06:53 Caffeine's prevalence in fitness
09:10 Eric's caffeine research background
11:04 Daily caffeine intake (1g/day of caffiene safe?)
17:30 Effective dosing by bodyweight and when high doses backfire
22:30 Tolerance and habituation: why your caffeine stops working
30:15 Caffeine withdrawal: symptoms, timeline, and how bad it actually gets
41:30 Caffeine sensitivity and genetics
44:00 Practical upper limits and sleep tradeoffs
48:00 Strategic caffeine use, deloads, and re-sensitizing
50:15 Different delivery forms: drinks, food, pills, and gum
53:45 Does caffeine Dehydrate you? Wrap-up and where to read more
Transcript
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| 0:00.0 | Welcome, everyone to the ARP Xring podcast. I'm Nick Shaw, joined by today. Dr. Eric Trexler, |
| 0:11.4 | welcome back to the podcast. Been on a number of times now, man. Super excited to have you back on. |
| 0:16.2 | How you doing? Pleasure to be here. Honored to be approaching the status of a regular. |
| 0:22.3 | Yeah. |
| 0:23.3 | Doing great and happy to chat with you. |
| 0:26.3 | Yeah. |
| 0:27.3 | Oh yeah. |
| 0:28.3 | So before we get into the nitty gritty on all the sciencey fitness stuff, you work up at Duke University in the fine state of North Carolina, which is where I also |
| 0:40.2 | reside. However, you are from Ohio originally. I am from Michigan originally. Duke, Michigan. |
| 0:49.5 | Actually, this weekend, you know what, by the time this is recording, this is going to be |
| 0:52.3 | well in the past tense, but we are recording days, just days before Michigan Duke basketball in Washington, D.C. |
| 1:00.6 | What is the word on the street up in Durham, North Carolina? |
| 1:05.2 | Well, first, I'm really concerned and kind of sad. I knew, because not only are we from the states of Ohio and Michigan, you went to Michigan |
| 1:15.6 | for undergrad. |
| 1:16.6 | I went to Ohio State, right? |
| 1:17.6 | So I knew that for about seven months out of the year because football season keeps getting |
| 1:22.6 | longer and longer, we were going to have issues. |
| 1:24.6 | But the saving grace was once basketball comes around, it'll be fine. |
| 1:29.5 | You know, Ohio State, our basketball program has just kind of withered away. |
| 1:34.7 | But now Duke and Michigan apparently have some issues because they're both vying for the top spot. |
| 1:41.1 | They're both top three teams going into this matchup. |
| 1:43.6 | The word on the street |
... |
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