Butyrate's Impact on Your Immune System
Dr. Joseph Mercola - Take Control of Your Health
Briana Mercola
4.6 • 1.5K Ratings
🗓️ 15 December 2025
⏱️ 8 minutes
🧾️ Download transcript
Summary
- Butyrate, a short-chain fatty acid produced when gut bacteria ferment dietary fiber, serves as both an energy source for colon cells and an important signaling molecule for immune regulation
- By inhibiting histone deacetylases (HDAC) and suppressing the NF-κB pathway, butyrate acts as a powerful anti-inflammatory agent, helping prevent chronic inflammation that contributes to various diseases
- Butyrate promotes regulatory T cell development while modulating other immune cells, helping maintain immune tolerance and preventing autoimmune responses while supporting balanced immune function
- Butyrate plays a significant role in managing chronic diseases like IBD, multiple sclerosis and Type 2 diabetes by reducing inflammation and supporting gut barrier function
- Emerging research suggests that butyrate influences brain health by modulating the gut-brain axis; it reduces neuroinflammation and supports cognitive function, and plays a supporting role in the prevention of neurological disorders like Alzheimer's disease and depression
Transcript
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| 0:00.0 | What if a single compound in your colon could calm inflammation, steady your immune system, and influence your brain health? |
| 0:07.3 | Welcome to Dr. Mercola's cellular wisdom. |
| 0:10.0 | Stay informed with quick, easy-to-listen summaries of our latest articles, perfect for when you're on the go. |
| 0:15.4 | No reading required. Subscribe for free at Mercola.com for the latest health insights. |
| 0:20.6 | Hello and welcome to Dr. Mercola's cellular wisdom. |
| 0:24.0 | I'm Ethan Foster and today we're examining beauty rate, how it's made in your gut, how it |
| 0:29.1 | regulates immune activity, and why its reach extends from your colon to systemic inflammation |
| 0:34.8 | and even cognition. |
| 0:36.2 | I'm Alara Sky and we'll keep this clear and practical. |
| 0:39.9 | You'll hear what butyrate is, how it modifies inflammatory signals, how it shapes T cells, |
| 0:45.4 | dendritic cells, and macrophages, and where research supports its role in conditions like |
| 0:50.5 | inflammatory bowel disease, multiple sclerosis, type 2 diabetes, and lupus. |
| 0:57.0 | Buterate is a short chain fatty acid produced when beneficial gut bacteria ferment dietary fiber in your colon. |
| 1:04.0 | It fuels your colon cells and helps maintain intestinal integrity. Beyond being an energy source, |
| 1:10.0 | it acts as a signaling molecule that |
| 1:12.0 | affects immune regulation, inflammation, and overall health. |
| 1:16.1 | A central way beauty rate reduces inflammation is by inhibiting histone deacetylases, the enzymes |
| 1:22.4 | that help switch genes on and off. When HDX are inhibited, anti-inflammatory genes are expressed more readily, |
| 1:30.3 | and pro-inflammatory activity is restrained. That genetic shift supports a steady, balanced |
| 1:36.3 | immune response instead of a chronic inflammatory state. |
| 1:40.3 | Another target is the NF-CAPA-B pathway, a master controller for cytokines, such as TNF-Alpha, |
| 1:47.0 | IL-6, and IL-1-BTA. |
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