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CoinDesk Podcast Network

Building Autonomous Health Systems in the Age of AI with Bryan Johnson

CoinDesk Podcast Network

CoinDesk

Business News, Daily News, News, Tech News

4.7698 Ratings

🗓️ 13 January 2026

⏱️ 30 minutes

🧾️ Download transcript

Summary

From building Braintree to launching Blueprint, Bryan Johnson reveals how the systems architecture of FinTech and the philosophy of crypto are powering a new, autonomous roadmap to reverse human aging and operationalize immortality. Founder and CEO of Blueprint and Don’t Die, Bryan Johnson, joins Gen C to discuss why the philosophy of crypto has the same mindset required to solve human aging. Bryan reveals how he is applying FinTech systems-thinking to the human body through "Autonomous Health" and bio-algorithms. We explore his journey to reverse his biological age and why the tech community is the primary driver of the next great evolution in human existence. - Links mentioned from the podcast:  Bryan's Twitter  Blueprint Website Don’t Die Website - Follow us on Twitter:  Sam Ewen, CoinDesk - From our sponsor: Check out CoinDesk's research report on KuCoin at: https://www.coindesk.com/research/kucoin-hits-record-market-share-as-2025-volumes-outpace-crypto-market - "Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

Transcript

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0:00.0

There's a philosophy that I share with crypto where there's a basic premise of rejecting inflation

0:08.5

and aging has the same philosophical underpinnings, rejecting aging. And it's the slow death

0:16.0

of an intelligent system. So I think we align very closely on that. So I just philosophically,

0:21.5

we're very similar. Then I think also longevity has such close adjacency to crypto.

0:32.1

All right, Sam here. Welcome to Gen C. I'm really excited this year, new year and new philosophy, we are going to be

0:40.1

kicking off a slightly different track. Last year, we really focused on who were the builders

0:44.9

building crypto brands. The year before that was AI, gaming and crypto. This year I really wanted to

0:50.8

focus on kind of who are interesting people who are challenging us to think

0:54.5

differently, but also who are building the future when it comes to their own personalized and

0:59.7

they're offering when it comes to the brands and the companies that they're building.

1:03.6

And just like who are folks who are having an effect on others and really making a difference.

1:08.0

So with that, we are going to kick off this year with Brian Johnson. Brian Johnson

1:12.4

as a CEO of Blueprint. He has this philosophy around longevity that a lot of people pay attention to.

1:18.0

And we just ought to be fascinating to both discuss that and some of his early interactions in the

1:23.5

crypto and payment space, which really got him to the opportunity to take the life that he has now into sort of the future as he's designing it. So with that, come back after the break.

1:33.5

New Gen C, New World, Brian Johnson. We'll see you soon.

1:36.8

Kucoin has cemented its spot as a top 10 exchange clearing over $1 trillion in volume this year.

1:42.5

A new Coin desk research Report details the dominant altcoin

1:45.5

strategy and resilient liquidity driving this growth. Discover more at CoinDesk.com forward slash research.

1:53.1

All right. Welcome back to Gen C. I'm here with Brian Johnson. Brian, I have so many questions,

1:56.8

really excited to talk to you. Because we are a crypto publication, though, I wanted to start

2:01.0

actually with your payments background. And I thought it was really fascinating. The more I sort of

...

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