Bugs and Drugs: Whipple Disease
Medgeeks with Andrew Reid
Medgeeks
4.8 ā¢ 996 Ratings
šļø 29 January 2024
ā±ļø 10 minutes
šļø Recording | iTunes | RSS
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Summary
In this latest Bugs and Drugs episode, we will discuss a very rare bacterial disease that primarily affects the gastrointestinal tract. However, it can affect other organs such as joints, heart and lungs. This infectious disease is known as Tropheryma whipplei or Whipple disease.
Your patient might present with chronic diarrhea, weight loss, abdominal pain and joint problems. To help you correctly diagnose this, you'll need to take some biopsies and imaging to identify the T. whipplei bacterium. Next, the treatments that can be offered are prolonged antibiotic therapy and potential surgical intervention.
Join Dr. Niket Sonpal as he dives deep into this enigmatic world of Whipple's disease.
January 29, 2024
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Transcript
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| 0:00.0 | Back in 1907 there was a physician who was very well known as George H. Whipple |
| 0:05.3 | who described a case of a 36 year old who had a lot of arthritis, |
| 0:09.7 | abdominal pain, and diarrhea. At the time he called it intestinal lipodystrophy. |
| 0:15.6 | And many of you might have heard Whipple and thought to yourself, |
| 0:17.9 | oh, is that Whipple's triad or Whipple's procedure? |
| 0:21.3 | Well, that's a different Whipple. This is George Hoyt Whipple's procedure? Well that's a different Whipple. This is George |
| 0:23.7 | Hoyt Whipple. The one you're thinking of is Alan Whipple, but this George |
| 0:28.3 | Whipple is actually pretty famous. He actually got the Nobel Prize in |
| 0:31.9 | physiology and he's well known because he basically |
| 0:34.7 | started the pathway to the discovery of Whipple's disease. |
| 0:38.6 | He described it in 1907 and it wasn't until 2003 when scientists were actually able to isolate it in |
| 0:44.8 | intestinal tissues. And this week in the podcast for bugs and drugs, I Dr. |
| 0:49.7 | Nachetson-Paul, your friendly-ne-neabored internist and and Gastroontrolologist, are going to be covering |
| 0:54.2 | Trophraima Whipply, the case of Whipples' disease. |
| 0:58.0 | So let's go through it. |
| 0:59.2 | Kue that music, my man. in. Now whipples. Now whipples. Now Whipple's disease is one that many of you remember from your basic science years. |
| 1:19.0 | It's caused by trophraima Wippe. |
| 1:21.0 | Now the reason why it's named that is in Greek trofe means nourishment and |
| 1:25.4 | Erema means barrier so right then and there the name is perfect because it causes |
| 1:30.0 | people to become malnourished and have rip-wearing diarrhea. |
| 1:33.4 | The investigation for this has lasted nearly 100 years, and the data tells us that though it's rare, |
| 1:38.8 | it affects men and women equally and more common in people over the age of 65. |
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