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Science Quickly

Budding Yeast Produce Cannabis Compounds

Science Quickly

Scientific American

Science

4.41.4K Ratings

🗓️ 28 February 2019

⏱️ 2 minutes

🧾️ Download transcript

Summary

Biologists have taken the genes that produce cannabinoids in weed and plugged them into yeast, making rare and novel compounds more accessible. Christopher Intagliata reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

This is Scientific American's 60 Second Science.

0:05.0

I'm Christopher Intagiata.

0:07.0

The compounds THC and CBD are known as

0:09.5

cannabonoids because they come from cannabis, aka marijuana.

0:14.0

Now biologists have taken the genes that produce canabonoids in weed

0:18.0

and plugged them into yeast.

0:20.0

Yeah, there's several reasons.

0:21.0

The first is cost.

0:22.0

Jay Kiesling is a synthetic biologist at UC Berkeley

0:25.0

who has previously programmed yeast to cheaply produce antramlarial drugs.

0:29.0

He says yeast could conceivably produce canabonoids

0:32.0

for about $400 a

0:33.4

kilogram that's compared to the $40,000 a kilo price tag

0:37.3

when using synthetic chemistry. Other benefits exist too. There are about a

0:41.7

hundred different

0:42.8

canabonoids that naturally occur in cannabis, but it's been really

0:46.7

hard to do research on those because there's not much available. They are

0:50.8

produced in such minute quantities in the cannabis that you'd have to

0:54.9

purify huge amounts of cannabis just to give a small quantity of them to test.

0:58.8

Kiesling says they can even make canappanoids that don't exist in nature at all by feeding the yeast certain fatty

1:04.6

acids.

1:05.6

The results in canabonoids, which are chemically similar, but not identical, to garden

...

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