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All-In with Chamath, Jason, Sacks & Friedberg

Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like

All-In with Chamath, Jason, Sacks & Friedberg

All-In Podcast, LLC

Entrepreneurship, Business, Technology

4.010.4K Ratings

🗓️ 26 March 2026

⏱️ 38 minutes

🧾️ Download transcript

Summary

(0:00) David Friedberg intros Bryan Johnson

(0:54) Why Bryan Johnson did 5-MeO-DMT

(12:56) What brain scans actually show

(18:36) Psychosis, bad trips, and life-altering decisions

(26:23) The next frontier: organoids and gene therapy

(33:26) GLP-1s, abundance, and human optimization

(35:35) The longevity drug nobody's talking about?

Thanks to our partner for making this happen!

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Intro Music Credit:

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Intro Video Credit:

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Transcript

Click on a timestamp to play from that location

0:00.0

Brian Johnson, thanks for being here.

0:01.5

Yeah, it's good to see you.

0:02.2

How are you feeling?

0:03.2

Maybe just share with us what you did a few days ago.

0:05.3

Yeah, I did five MEO DMT, which is the most powerful psychedelic on the planet.

0:13.2

It's somewhere between five and ten times more powerful than DMT.

0:17.8

And so, yeah, it's, so it's been 48 hours.

0:21.3

I'm still learning how to talk about it.

0:27.7

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0:32.5

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0:34.4

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0:37.4

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0:38.1

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0:43.2

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0:49.6

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0:58.0

Before we get into your experience, why did you choose to do it? Two things. One, mostly as a longevity experiment.

1:01.0

So when I started this project five years ago, the approach we had was go through all the scientific evidence ever published on health and longevity.

1:09.5

Try to find the interventions that have the best evidence ever published on health and longevity, try to find the interventions

1:11.2

that have the best evidence for effect size, and we just went down on the list from top

1:16.5

performing on down. So of course, you start with exercise, nutrition, sleep, and you work your way

1:23.4

down to things like hyperbaric oxygen therapy and sauna and then rapamycin

1:28.1

malformin. And so we never actually had on our radar psychedelics. They were always either

...

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