Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
All-In with Chamath, Jason, Sacks & Friedberg
All-In Podcast, LLC
4.0 • 10.4K Ratings
🗓️ 26 March 2026
⏱️ 38 minutes
🧾️ Download transcript
Summary
(0:00) David Friedberg intros Bryan Johnson
(0:54) Why Bryan Johnson did 5-MeO-DMT
(12:56) What brain scans actually show
(18:36) Psychosis, bad trips, and life-altering decisions
(26:23) The next frontier: organoids and gene therapy
(33:26) GLP-1s, abundance, and human optimization
(35:35) The longevity drug nobody's talking about?
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Transcript
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| 0:00.0 | Brian Johnson, thanks for being here. |
| 0:01.5 | Yeah, it's good to see you. |
| 0:02.2 | How are you feeling? |
| 0:03.2 | Maybe just share with us what you did a few days ago. |
| 0:05.3 | Yeah, I did five MEO DMT, which is the most powerful psychedelic on the planet. |
| 0:13.2 | It's somewhere between five and ten times more powerful than DMT. |
| 0:17.8 | And so, yeah, it's, so it's been 48 hours. |
| 0:21.3 | I'm still learning how to talk about it. |
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| 0:58.0 | Before we get into your experience, why did you choose to do it? Two things. One, mostly as a longevity experiment. |
| 1:01.0 | So when I started this project five years ago, the approach we had was go through all the scientific evidence ever published on health and longevity. |
| 1:09.5 | Try to find the interventions that have the best evidence ever published on health and longevity, try to find the interventions |
| 1:11.2 | that have the best evidence for effect size, and we just went down on the list from top |
| 1:16.5 | performing on down. So of course, you start with exercise, nutrition, sleep, and you work your way |
| 1:23.4 | down to things like hyperbaric oxygen therapy and sauna and then rapamycin |
| 1:28.1 | malformin. And so we never actually had on our radar psychedelics. They were always either |
... |
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