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Science Quickly

Blood Pressure Vaccine Lengthens Rat Lives

Science Quickly

Scientific American

Science

4.2639 Ratings

🗓️ 29 May 2015

⏱️ 2 minutes

🧾️ Download transcript

Summary

A DNA-based vaccine gave rats six months of protection against high blood pressure as well as healthier hearts. Christopher Intagliata reports Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Understanding the human body is a team effort. That's where the Yachtel group comes in.

0:05.8

Researchers at Yachtolt have been delving into the secrets of probiotics for 90 years.

0:11.0

Yacold also partners with nature portfolio to advance gut microbiome science through the global grants for gut health, an investigator-led research program.

0:19.6

To learn more about Yachtolt, visit yawcult.co.

0:22.7

J-P. That's Y-A-K-U-L-T dot-C-O-J-P. When it comes to a guide for your gut, count on Yacol.

0:33.3

This is Scientific American 60 Second Science. I'm Christopher Ndalata. Got a minute?

0:39.5

Some 70 million American adults have high blood pressure.

0:43.2

Three quarters of them rely on medication to keep the condition in check.

0:47.1

But you've got to remember to actually take the daily dose.

0:50.3

Now researchers have devised a longer-lasting alternative,

0:53.6

a vaccine to lower blood pressure, for rats at least.

0:58.1

Scientists jabbed hypertensive rats with three doses of the formulation. It's a DNA vaccine,

1:03.3

containing DNA fragments from angiotensin 2, a hormone that boosts blood pressure, as well as fragments

1:09.4

from hepatitis B to guarantee the immune

1:11.6

system's attention. Cells suck up the vaccine's DNA and start pumping out the proteins the DNA

1:17.5

codes for. When the host defenses get a whiff of the proteins, it reacts. It really revs up against

1:23.2

the hepatitis B fragments, and while it's at it, it starts taking out some angiotensin 2 as well.

1:29.5

The result is a reduction in angiotensin 2's usual blood pressure-raising effects,

1:34.5

similar to what blood pressure meds like Benicar do.

1:37.6

Less angiotensin 2 means more relaxed blood vessels, and a drop in pressure.

1:42.5

That effect lasted six months in the vaccinated rats

1:45.6

and lengthen their lifespan by eight weeks. Necropsy's on the vaccinated rats revealed healthier

...

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