BIG T Trauma Series Ep. 21: All Things TXA

Behind The Knife: The Surgery Podcast

Science, Health & Fitness, Medicine, Education

4.8 • 1.4K Ratings

🗓️ 13 March 2025

⏱️ 49 minutes

🔗️ Recording | iTunes | RSS

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Summary

Join Patrick Georgoff as he welcomes Dr. Gene Moore and Dr. Ian Roberts, two giants in trauma surgery and epidemiology, to discuss tranexamic acid (TXA) in trauma care. Dr. Moore, a legendary trauma surgeon and researcher, and Dr. Roberts, the architect of the CRASH trials, break down the science, controversies, and practical applications of TXA. They explore who should get TXA, when it should be given, optimal dosing, and its potential risks. With insights from landmark trials like CRASH-2, STAMP, PATCH, and ROC TXA, this episode cuts through the confusion surrounding TXA in trauma and traumatic brain injury. Is early administration the key to saving lives? Should TXA be given intramuscularly prehospital? Tune in as we tackle these critical questions and define the future of TXA in trauma care!

This episode of Big T Trauma was sponsored by Teleflex, a global provider of medical devices. Learn more at teleflex.com and at the Teleflex Trauma and Emergency Medicine LinkedIn page.

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BIG T Trauma Series: https://app.behindtheknife.org/podcast-series/big-t-trauma

Transcript

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0:00.0	Behind the Night, the Surgery podcast, relevant and engaging content designed to help you dominate the day. This episode of Big T trauma is sponsored by Teleflex, a global provider of medical devices that address the time-critical challenges of achieving vascular access and bleeding control.
0:31.8	Not all products are available in all regions.
0:34.1	To learn more, visit Teleflex.com.
0:41.0	Calling all surgical education junkies.
0:45.3	Behind the Knife is looking to add new fellows to our team this year. We are thrilled to be adding these positions as we've got big plans for the future and we want you to be a part of them.
0:50.9	We're working on countless projects that will make a real impact on surgical education, including a modern, engaging general surgery curriculum, and slick new videos.
1:00.4	We're looking for enterprising and surgical residents to take the bowl by the horns and build something new and exciting.
1:06.9	Fellows will benefit from ample support from the behind-the-knife team, including the use of our brand new digital education platform and access to all of our resources like illustrators, video editing, social media, and more.
1:19.3	Get your name out there and build your CV by being part of the number one surgery education platform in the world.
1:25.3	We're offering a two-year fellowship starting in July 2025 and ending in
1:29.6	June 2027. Only residents beginning their two-year academic development time will be considered,
1:35.2	and the residents' institutions and mentors must approve of this fellowship. Check out the show
1:40.6	notes for the application link. All applications are due April 20th.
1:44.8	Again, all applications are due on April 20th.
1:48.8	Dominate the day.
1:52.5	Yeah, I can imagine that could be true.
1:54.7	I really don't know.
1:56.8	Like, the thing about randomized trials is they give you the answer.
2:04.6	In the crash two trial, there was less deaths in the Trenic acid group. But why it's a hypothesis, isn't it really?
2:12.6	It's seen you have to have two grams again on effect,
2:16.6	and yet two grams is where we start seeing the adverse effect.
2:20.5	So that's why, again, I stay on our track of trying to pick the right patient.
	...

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