Bats Beat Ebola with Hypervigilant Immunity
Science Quickly
Scientific American
4.4 • 1.4K Ratings
🗓️ 29 February 2016
⏱️ 2 minutes
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| 0:00.0 | This is scientific American's 60 second science. I'm Christopher Intalyata. Got a minute? |
| 0:07.0 | When a virus invades your cells, it kicks your immune machinery into motion. |
| 0:11.0 | And the first responders are signaling proteins called interferons. |
| 0:15.6 | And they trigger downstream immune responses. So you can kind of think of them as |
| 0:20.9 | kind of the hormones of the immune system. They're triggered and then |
| 0:24.8 | they stimulate a bunch of other immune responses that are more specific to |
| 0:28.2 | that pathogen. Michelle Baker, a comparative immunologist at the Australian |
| 0:32.2 | Animal Health Laboratory. |
| 0:34.0 | In the spirit of comparative immunology, Baker and her colleagues looked at how another mammal, |
| 0:38.5 | the black flying fox, a type of bat, handles infections. |
| 0:42.8 | They sequenced its immunity genes |
| 0:44.7 | and observed the immune response in normal bat cells. |
| 0:47.7 | And they found that, unlike us, |
| 0:49.4 | the bats always have interferons on patrol, |
| 0:52.3 | meaning the proteins don't wait to be activated by invaders. |
| 0:56.3 | And the researchers say that this constant state of high alert may be why bats can carry |
| 1:01.0 | Ebola, NEPA virus, and a whole host of other infections, with no symptoms at all. |
| 1:07.0 | The findings appear in the proceedings of the National Academy of Sciences. |
| 1:11.2 | So why not switch on those interferons 24-7 in humans? |
| 1:15.0 | Well, in us they tend to cause lots of inflammation and cell damage. |
| 1:19.0 | Like the symptoms you feel from the flu, |
| 1:21.0 | a lot of that's your immune system's fault, but the key might be to do as the bats do. |
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