Auvelity: 4 Controversies

The Carlat Psychiatry Podcast

Pocket Psychiatry: A Carlat Podcast

Health & Fitness, Mental Health, Medicine, Alternative Health

4.8 • 440 Ratings

🗓️ 12 February 2024

⏱️ 17 minutes

🔗️ Recording | iTunes | RSS

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Summary

Auvelity, a new rapid acting medication for depression, is a branded combination of two generic drugs. We look at its side effects, addictive potential, and whether you can just use the generic components.CME: Take the CME Post-Test for this Episode (https://www.thecarlatreport.com/blogs/2-the-carlat-psychiatry-podcast/post/4613-auvelity-4-controversies)Published On: 02/12/2024Duration: 16 minutes, 44 secondChris Aiken, MD, and Kellie Newsome, PMHNP have disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.

Transcript

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0:00.0	Avality, the first fast-acting antidepressant.
0:04.3	Or is it?
0:05.5	Today, we look at four controversies with this dextromothorfen bupropion combo.
0:14.5	Welcome to the Carlyte Psychiatry Podcast, keeping psychiatry honest since 2003.
0:20.4	I'm Chris Sagan, the editor-in-chief of the Carlat Psychiatry Report.
0:24.1	And I'm Kelly Newsom, a psychiatric MP and a dedicated reader of every issue.
0:31.3	We pick up again with a velity.
0:33.9	The med that augments with velocity.
0:36.6	Last week, we learned this combination of Euproprproprion and dextromothorfin
0:40.6	does indeed work fast, within a week, and is more effective than buproprion alone.
0:47.0	But despite those accolades, it missed the mark in treatment-resistant depression.
0:51.7	Today, we're going to talk about its side effects and cover four
0:54.7	controversies with the drug. One, is it addictive? Two, does it work long term? Three, can you just
1:03.9	use a generic components? And four, is it really any different from a popular speed up strategy
1:10.4	from the 1980s?
1:12.7	We're going to start with its side effects, but first, a preview of the CME quiz for this episode.
1:36.3	What is the main risk of combining dextromithorfan with other antidepressants besides buproprion? A. Neuroleptic malignant syndrome.
1:41.3	B. Only buproprion will inhibit dextramathorphans metabolism.
1:48.0	C.
1:49.7	Serotonin syndrome.
1:52.0	Or D.
1:53.8	neurotoxicity. In last week's episode, we learned that dextromythorfen makes buproprion work faster and boosts its
	...

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