Aug 29 2025 This Week in Cardiology
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 29 August 2025
⏱️ 34 minutes
🔗️ Recording | iTunes | RSS
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Summary
CAC 0 takes a gut punch, ICD therapies cannot be surrogates for benefit, and two important trials from ESC are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I CAC 0
- LDL-C and CVD Risk With CAC Score 0 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf497/8228645
II ICD Therapies
- Contemporary ICD Benefit https://www.jacc.org/doi/10.1016/j.jacep.2025.06.028
- PROFID Trial https://profid-project.eu/profid-ehra-trial/
- MADIT-RIT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1211107
- Declining Risk of Sudden Death in HF https://www.nejm.org/doi/full/10.1056/NEJMoa1609758
III Digit-HF
- DIGIT-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415471
- Digoxin–Mortality: Comparison in the DIG trial https://academic.oup.com/eurheartj/article/40/40/3336/5520008
IV POTCAST
- POTCAST trial https://www.nejm.org/doi/full/10.1056/NEJMoa2509542
ESC Preview
IV HTN Guidelines
- New Blood Pressure Guidelines: 4 Things I Like and 2 Concerns https://www.medscape.com/viewarticle/new-blood-pressure-guidelines-4-thing-i-and-2-concerns-2025a1000m1x
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Transcript
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| 0:00.0 | You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology. |
| 0:05.4 | This podcast is intended for health care professionals only. Any views expressed are the |
| 0:10.0 | presenters own and do not necessarily reflect the views of WebMD or Medscape. |
| 0:14.9 | Hi, everyone. This is John Mandrola from the heart.org medscape cardiology, and this is this week in cardiology for August 29th, |
| 0:25.2 | 2025. I'm recording in Madrid, Spain. I am at the EFC meeting. Today's podcast will be a little longer |
| 0:33.2 | because we have really exciting news from EFC. Other things that I'll discuss today |
| 0:38.8 | are that the CECC zero people take a gut punch. |
| 0:42.9 | ICD therapies cannot be surrogates for benefit. |
| 0:46.6 | And boy, is EFC really getting good? |
| 0:49.1 | And I'll have two reports of two important trials on the first day. |
| 0:53.9 | But let's start and talk about |
| 0:55.7 | coronary artery calcium and a recent study from Denmark. Now, proponents of coronary |
| 1:01.4 | artery calcium scans suggest that the scans can enhance risk stratification. Specifically, |
| 1:08.7 | the scans enhance risk estimates over and above the pooled cohort equation. |
| 1:14.5 | The PCE equation calculates, no, no wait, it estimates 10-year risk for a cardiac event. |
| 1:21.8 | For instance, your 10-year risk could be 5%, 7%, 15%. |
| 1:27.5 | And while these numbers seem quantitative and impressive, the truth is that patients and |
| 1:33.4 | doctors alike inherently sense heart disease risk. |
| 1:38.0 | For instance, if you are old or have high cholesterol or hypertension or diabetes |
| 1:43.6 | or smoking, you're going to have a high risk. |
| 1:48.1 | So enter corner artery calcium scans, KAC scans. |
| 1:52.5 | While proponents will emphasize two outcomes from corner artery screening, A, the scan could |
... |
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