Aug 23 2024 This Week in Cardiology
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 23 August 2024
⏱️ 33 minutes
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Summary
Suicidal ideation and GLP-1 agonists, a repeat of PARADIGM HF in Chagas CM, CASTLE HTx critical appraisal, and primary prevention of SCD in HF are the topics John Mandrola, MD, covers this week.
This podcast is intended for healthcare professionals only.
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I. Suicidal ideation with GLP-1
Signal of Suicidality With GLP-1 RA Semaglutide, but Experts Urge Caution
https://www.medscape.com/viewarticle/signal-suicidality-glp-1-ra-semaglutide-experts-urge-caution-2024a1000fa7
- Disproportionality Analysis from World Health Organization Data on Semaglutide, Liraglutide, and Suicidality
- Variability in Disproportionality paper https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.668765/full
II. PARACHUTE HF: Repeating the Mistakes in PARADIGM HF
- PARACHUTE HF https://www.jacc.org/doi/10.1016/j.jchf.2024.05.021
- SOLVD https://www.nejm.org/doi/full/10.1056/NEJM199108013250501
- CONSENSUS trial https://www.nejm.org/doi/full/10.1056/NEJM198706043162301
- Meta-analysis of Low vs High Dose ACE/ARB https://doi.org/10.1161/CIRCHEARTFAILURE.117.003956
- Meta-analysis of Sac/Val vs ARB/ACE Inhibitors https://link.springer.com/article/10.1007/s00228-024-03686-6
- PARADISE MI https://www.nejm.org/doi/full/10.1056/NEJMoa2104508
III. CASTLE HTx Critical Appraisal
- Critical Appraisal of CASTLE HTx https://doi.org/10.1016/j.jacc.2024.06.020
- CASTLE HTx https://www.nejm.org/doi/10.1056/NEJMoa2306037
- CASTLE AF https://www.nejm.org/doi/full/10.1056/NEJMoa1707855
IV. More Data Suggesting Modest Benefits of the Primary Prevention ICD
- First and Recurrent ICD Shocks: JICE Paper from Denmark https://link.springer.com/article/10.1007/s10840-024-01873-0
- HF trialists https://www.nejm.org/doi/full/10.1056/NEJMoa1609758
PROFID Trial https://profid-project.eu/ - DANISH https://www.nejm.org/doi/full/10.1056/NEJMoa1608029
- SCD-HeFT https://www.nejm.org/doi/full/10.1056/NEJMoa043399
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Transcript
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| 0:00.0 | You're listening to this week in cardiology from the heart |
| 0:03.5 | org medscape cardiology this podcast is intended for health care |
| 0:07.6 | professionals only any views expressed are the presenters own and do not |
| 0:11.3 | necessarily reflect the views of WebMD or Medscape. |
| 0:15.1 | You can now access the latest in medical news on your Amazon Alexa-enabled device. |
| 0:19.7 | Join me, Perry Wilson, every weekday morning for Medscape Medical Minute where I highlight the top |
| 0:24.8 | medical stories of the day. |
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| 0:30.1 | Minute on Amazon and click enable or open the Amazon Alexa app go to |
| 0:34.4 | skills search for Medscape Medical Minute and click enable then say Alexa |
| 0:39.6 | what's the news or Alexa what's my flash briefing I hope you'll join us. |
| 0:44.6 | Hi everyone this is John Mandrola from the heart.org medscape |
| 0:50.3 | and this is this week in cardiology for August 23rd, 2024. |
| 0:55.0 | This week, suicidal ideation and the GLP1 drugs, |
| 1:00.0 | a repeat of paradigm HF in Shaugus cardiomyopathy. |
| 1:05.5 | Castle H.T.X. gets a serious critical appraisal in the journal Jack |
| 1:11.0 | and primary prevention of sudden cardiac death and heart failure is |
| 1:15.5 | definitely changing. First up is suicidal ideation with GLP1 drugs. |
| 1:21.4 | Jama Network Open has published a drug safety study on the GLP1 agonist |
| 1:27.1 | semagglutide that is making neurons in the media. |
| 1:31.4 | I have read the study and have one clear thing to say. |
| 1:35.0 | Pharmacovigilance is quite complicated. |
... |
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