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This is an audio long read from nature. In this episode, The Secret Lives of Sells,

as never seen before. Written by Diana Kwan and read by me, Benjamin Thompson.

For a few weeks in 2017, Wanda Kukulski found herself binge-watching, an unusual kind of film.

Videos of the insides of cells. They were made using a technique called cryo-electron

tomography, or cryo-et, that allows researchers to view the proteins in cells at high resolution. In these videos,

she could see all kinds of striking things, such as the inner workings of cells and the

compartments inside them in unprecedented detail. I was so overwhelmed by the beauty and the complexity

that in the evenings I would just watch them like I would watch a documentary,

recalls Kukulski, a biochemist at the University of Bern, Switzerland.

In recent years, imaging techniques such as cryo-ET have started to enable scientists to see biological molecules in their native environments.

Unlike older methods that take individual

proteins out of their niches to study them, these techniques provide a holistic view of proteins

and other molecules together with their cellular landscape. Although they still have limitations,

some researchers say that the resolution of cryo-ET, for example, is too low for molecules to be

identified with certainty, the techniques are increasing in popularity and sophistication.

Researchers who turn to them are not only mesmerized by the beautiful images, but also blown

...