Are Brain-Computer Interfaces Actually Ready for Humans?
This Week in Startups
Jason Calacanis
4.2 • 1.4K Ratings
🗓️ 16 March 2026
⏱️ 74 minutes
🧾️ Download transcript
Summary
This Week In Startups is made possible by:
Caldera + Lab - https://CalderaLab.com/TWIST
Northwest Registered Agent - https://northwestregisteredagent.com/twist
Lemon - https://Lemon.io/twist
Today’s show:
Computers that read your mind? Jets that are all wings? Continuously tracking your body’s vital signs to live longer? We’ve got all that and more on the show today.
First, we sat down with the CEO of Paradromics, Matt Angle, to dig into the progress that his brain-computer interface startup has made. Yes, there are more companies working on BCIs than just Neuralink. Paradromics, in particular, is looking for early clinical trial subjects as it works to bring its technology out of the lab and into the market.
If you ever wanted to know more about how BCIs work and how long it will be until we can all benefit from the tech, this is the interview for you.
Next, we got JetZero CEO Tom O'Leary on the phone to tell us all about his startup’s jet. No, it’s not competing with Boom, a startup that wants to build a supersonic passenger airliner. Instead, JetZero is building jets that are mostly wing, allowing them to fly with far greater fuel efficiency. Best of all? The future JetZero planes can fit right into normal airports.
Finally, we chatted with Nutrisense CEO Dan Zavorotny. While keeping tabs on your glucose levels may not be the sexiest topic in the world, the data that continuous monitoring can bring is incredibly valuable health information. Mix that signal with coaching, and Nutrisense reckons its combination of software, data, and dieticians can really improve health outcomes for its customers.
If you needed a break from pure-play AI news, TWiST has you covered!
Timestamps:
0:00 Introduction
1:47 Paradromics
3:26 How do BCIs read your mind?
9:58 Lemon - Get 15% off your first 4 weeks of developer time at Lemon.io/twist
19:54 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at northwestregisteredagent.com/twist
27:24 JetZero
29:07 The advantages of more wing
30:13 Caldera Lab - Whether you're starting fresh or upgrading your routine, Caldera Lab makes skincare simple and effective. Head to CalderaLab.com/TWIST and use TWIST at checkout for 20% off your first order.
55:30 Nutrisense
Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com
Check out the TWIST500: https://www.twist500.com
Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp
Follow Lon:
Follow Alex:
LinkedIn: https://www.linkedin.com/in/alexwilhelm
Follow Jason:
LinkedIn: https://www.linkedin.com/in/jasoncalacanis
Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland
Check out Jason’s suite of newsletters: https://substack.com/@calacanis
Follow TWiST:
Twitter: https://twitter.com/TWiStartups
YouTube: https://www.youtube.com/thisweekin
Instagram: https://www.instagram.com/thisweekinstartups
TikTok: https://www.tiktok.com/@thisweekinstartups
Substack: https://twistartups.substack.com
Transcript
Click on a timestamp to play from that location
| 0:00.0 | Hello everybody and welcome back to Twist. This is Alex. Today is Monday, March 16th, |
| 0:05.9 | 2000 and we have three amazing interviews with world-class, world-changing founders coming your |
| 0:12.3 | way. First up, we're going to talk to paradromics. They are building brain computer interfaces. |
| 0:17.7 | Yes, BCIs really are coming. Then we're talking to Jet Zero, which brings me to a question, what if you had a plane, right? And it was just one big giant wing. Then we have Nutrisense. Yes, I know health tracking is all the rage because it's fair enough. Knowing what's going on in your body is a pretty important thing if you want to Health Max. And Maxing's a big deal these days. I mean, just look at me. |
| 0:38.3 | I'm looks maxing right now. Nutrisense, I think, is on the cutting edge of consumer health and so I |
| 0:43.5 | wanted to learn more. It's a great show. I learned a lot. I hope you enjoy it. We're back on Wednesday. |
| 0:48.3 | Let's have some fun. This weekend startups is brought to you by Caldera Lab. |
| 0:54.9 | Whether you're starting fresh or upgrading your routine, Caldera Lab makes skincare simple and effective. |
| 1:00.9 | Head to calderaLab.com slash twist and use Twist at checkout for 20% off your first order. |
| 1:08.0 | Northwest Registered Agent. |
| 1:09.5 | Get more when you start your business with Northwest. |
| 1:12.4 | In 10 clicks in 10 minutes, you can form your company and walk away with a real business identity. |
| 1:18.1 | Learn more at Northwest Registeredagent.com slash twist. |
| 1:22.3 | And Lemon. |
| 1:23.4 | Building a great team is essential to any business. |
| 1:26.2 | Lemon is a marketplace of vetted, experienced engineers ready to take your company to the next level. |
| 1:32.0 | Get 15% off your first four weeks of developer time at lemon.io slash twist. |
| 1:40.2 | If you are an AI fan, you must have heard about the big hype in talking to your AI, talking to your agents, using your voice. Well, that's well and good if you have that capability, if that's in your personal capacity. But what if your body doesn't quite do what you want it to do? You're going to need a little bit of help. And that's why I'm really excited that companies like Parodromics are working on taking BCIs out of the lab and putting them into our brains, |
| 2:02.4 | not only so we can do cool stuff, but also so that everyone can participate in the future digital and AI revolution. |
| 2:08.1 | So please join me and welcoming to the show. It's Matt Engel from Parodromics. Matt, how you doing? |
| 2:13.2 | Good. Thanks for having me. Dude, my absolute pleasure. I love brain computer interfaces because although I can type very |
| 2:18.7 | quickly, I really do think though that my hands slow me down and as AI gets faster, I just |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Jason Calacanis, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Jason Calacanis and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2026.