Apr 19 2024 This Week in Cardiology
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 19 April 2024
⏱️ 29 minutes
🧾️ Download transcript
Summary
ACC Part 2: The TACT2 trial of chelation, inter-atrial shunts for HF, and triglyceride lowering; plus diltiazem and Factor Xa anticoagulants are the topics John Mandrola, MD, covers this week.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. TACT 2
Chelation Therapy Provides No Benefit Post-MI
https://www.medscape.com/viewarticle/chelation-therapy-provides-no-benefit-post-mi-2024a10006l5
Chelation Therapy and CV Risk: Why TACT2 Showed No Benefit https://www.medscape.com/viewarticle/chelation-therapy-and-cv-risk-why-tact2-showed-no-benefit-2024a1000761?src=
- JAMA TACT 1 paper https://jamanetwork.com/journals/jama/fullarticle/1672238
- Diabetes Subgroup paper https://pubmed.ncbi.nlm.nih.gov/24254885/
- A New Look at P-values https://evidence.nejm.org/doi/abs/10.1056/EVIDoa2300003
- PARAGON HF https://www.nejm.org/doi/full/10.1056/NEJMoa1908655
II. Interatrial Shunts for HF
No Net HF Benefit for Interarterial Shunt Device
https://www.medscape.com/viewarticle/no-net-hf-benefit-interarterial-shunt-device-2024a10006kk
- REDUCE LAP HF II https://doi.org/10.1016/S0140-6736(22)00016-2
III. Triglyceride Lowering
Early Olezarsen Results Show 50% Reduction in Triglycerides
https://www.medscape.com/viewarticle/early-olezarsen-results-show-50-reduction-triglycerides-2024a10006oz
Is It Time to Stop Treating High Triglycerides?
https://www.medscape.com/viewarticle/990126
- NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2402309
Substantial Triglyceride Reduction With Plozasiran
https://www.medscape.com/viewarticle/substantial-triglyceride-reduction-plozasiran-2024a10006wf?icd=login_success_email_match_norm
- JAMA Cardiology https://jamanetwork.com/journals/jamacardiology/article-abstract/2817469
IV. Diltiazem and Factor Xa inhibitors
- JAMA Vanderbilt University Paper https://jamanetwork.com/journals/jama/fullarticle/2817546
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Questions or feedback, please contact news@medscape.net
Transcript
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| 0:00.0 | You're listening to this week in cardiology from the heart |
| 0:03.4 | org medscape cardiology this podcast is intended for health care |
| 0:07.6 | professionals only any views expressed are the presenters own and do not |
| 0:11.2 | necessarily reflect the views of WebMD or Medscape. |
| 0:15.1 | You can now access the latest in medical news on your Amazon Alexa-enabled device. |
| 0:19.7 | Join me, Perry Wilson, every weekday morning for Medscape Medical Minute where I highlight the top |
| 0:24.7 | medical stories of the day. |
| 0:26.5 | To add Medscape Medical Minute to your flash briefing, search for Medscape Medical |
| 0:30.1 | Minute on Amazon and click enable or open the Amazon Alexa app go to skills |
| 0:34.7 | search for Medscape Medical Minute and click enable then say Alexa what's the |
| 0:40.1 | news or Alexa what's my flash briefing I hope you'll join us. |
| 0:44.0 | Hi everyone this is John Mandrola from the Heart |
| 0:47.6 | org medscape cardiology and this is this week in |
| 0:51.2 | cardiology for April 19th, 2024. |
| 0:55.0 | This week I'll do a second ACC recap. |
| 0:59.0 | We'll do the TAC-2 trial of Kealation Therapy. We'll do Relieve H.F. which is |
| 1:05.8 | interatrial shuns for heart failure. We'll do a couple of triglyceride lowering |
| 1:10.8 | trials and an interesting trial on Diltayasam Infactor 10A anticoaguments. |
| 1:17.0 | First, TAC2. |
| 1:20.0 | Let's start with a trial that teaches a vital lesson in critical appraisal and scientific skepticism. |
| 1:27.0 | I lead with this trial for an important reason. |
| 1:30.0 | Tectu studied pulation of heavy metals as a treatment for atherosclerotic vascular disease in patients who had diabetes. |
... |
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