Antimicrobial Resistance of Bacteria and CRISPR Genome Engineering Techniques Discussed with Gaetan Burgio
Finding Genius Podcast
Richard Jacobs
4.4 • 1K Ratings
🗓️ 9 June 2021
⏱️ 21 minutes
🧾️ Download transcript
Summary
How can bacteria that have become resistant to treatment be overcome? Using genome engineering may be the technique that allows treatment to overcome the infection once again.
Press play to learn:
- How bacteria become resistant
- How the virome reacts to gaining resistance
- How bacteria avoid the immune system
Gaetan Burgio, a group leader of the Burgio Group as a part of Australia National University, shares his experience working with AMR bacteria.
Some bacteria may build resistance to any treatments or antibiotics over time through mutation or other genomic changes. However, CRISPR techniques have allowed researchers to pinpoint how a bacterium is resistant and alter it at a genomic level.
By evaluating how these bacteria have become resistant and how the microbiome changes, we can determine how various phages affect virulence. Evading the immune system is the primary mode of resistance, and by lowering virulence, it will remain undetected within the body, avoiding an immune reaction.
Search for @GaetanBurgio on Twitter for more information.
Episode also available on Apple Podcasts: apple.co/30PvU9C
Transcript
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| 0:00.0 | Forget frequently as questions, common sense, common knowledge, or Google. |
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| 0:06.8 | 95% of people in any profession are good enough to be qualified in license. |
| 0:11.2 | 5%? |
| 0:12.0 | Go above and beyond. |
| 0:13.0 | They become very good at what they do. |
| 0:14.8 | But only 0.1% are real geniuses. |
| 0:18.0 | Richard Jacobs has made his life's mission to find them for you. |
| 0:22.1 | He hunts down and interviews geniuses in every field. |
| 0:24.9 | Sleep science, cancer, stem cells, ketogenic diets, and more. |
| 0:28.6 | Here come the geniuses. |
| 0:30.2 | This is the Finding Genius Podcast. |
| 0:32.8 | The Richard Jacobs. |
| 0:37.6 | Before we begin, a note from our sponsor. |
| 0:40.0 | I'm Richard Jacobs, executive director of the non-profit |
| 0:43.0 | Finding Genius Foundation, and host of the Finding Genius Podcast. |
| 0:46.5 | In late 2016, I was rear-ended at 65 miles an hour by a truck on the highway, |
| 0:52.0 | which sent me off-road into a ditch. |
| 0:54.6 | The impact of the collision gave me a concussion and other injuries. |
| 0:58.2 | At the hospital, a CT scan showed that I had thyroid nodules, which turned out to be cancer. |
| 1:03.2 | It was then when I had a biopsy in my neck that I realized, even if I was a million there, |
| 1:08.0 | I wouldn't want a second or a third biopsy due to the pain and the invasiveness of it. |
... |
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