Team what's happening Zach here from med geeks so today we're going to change gears

no case today no systematic review today today we're doing pharmacology

I want to review anti coagulation any agent that inhibits one or more steps of that coagulation cascade.

We're going to review the old, the new anticoagulants, and then next week we're going to talk

about when it gets ugly, aka when you need to reverse those anticoaguline effects. So I split this up because it's a large

topic to digest. I'm going to keep it simple, 30,000 foot view. We're going to go over mechanism of action,

indications, precautions, adverse effects,

monitoring, and then some dosing of the medications.

So before we get started, it's impossible to talk about anti-coagulation

without talking about the coagulation cascade.

So if you happen to recall that picture in your head,

you got the intrinsic and extrinsic pathways.

So intrinsic is when there's trauma to stuff inside the vascular system, aka intrinsic.

Then there's extrinsic pathway, and this is trauma to the extra vascular tissue

or the actual vascular wall itself.

So it isn't something extrinsic.

So a side note, that's something I learned along the way

is that there's A's.

So when you look at that coagulation cascade picture there's

10 A, 2A, so the A's they stand for activated so 10A is factor 10 in the activated form.

2A is factor 2 in the activated form, etc.

So both pathways converged to form the factor 10A, which converts pro-Thrombin which is factor 2

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