Welcome everybody to another episode of Dr. Matt and Dr. Mike's A to Z of the Human Body.

I'm your host, Dr. Mike Todorovich, and I'm joined by my co-host Q-Tip. How you going?

I tried to do 100 sit-ups in a row yesterday, but I didn't finish. My stomach couldn't handle that kind of abuse.

All right. Angiotensin 1 and 2 is the topic today. And the last episode, or at least it would have been the last or the one before that was a related topic.

So that helps.

Angiotensinogen.

And we said in that topic that angiotensinogen is a protein that's involved in blood pressure

and it's inactive.

And it needs to be activated.

And we said that angiotensinogen is activated by a protein called rennan very good and

slow so renin is produced and released by the kidneys predominantly and the kidneys will chop

10 amino acids off angiotensinogen and it does this to produce angiotensin 1 so that's the first

one we're going to focus on angiotensin 1 so angiotensin 1. So that's the first one we're going to focus on.

Angiotensin 1.

So angiotensin 1 is also called pro angiotensin because it, its job, Matt, is to do nothing, really,

just to be a precursor.

I don't know why that's the case because it sort of seems like it's, I don't know why

biology would add an additional step when it doesn't need to. So I'm sure that either it does

play a role somewhere or its role was once important and now probably disappeared. Yeah. So it's what we, I think this is probably appropriate use of the term, called a spandrel.

So it has just come along for the ride through evolution.

It doesn't necessarily play a role or a function explicitly, but it's coming along for the ride.

So its job is to be a precursor to produce

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