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Hospital and Internal Medicine Podcast

Anemia of Inflammation - part 3

Hospital and Internal Medicine Podcast

Gil Porat, M.D., FACP, CPT

Health & Fitness, Fitness, Science, Health & Fitness:medicine, Medicine

4.7587 Ratings

🗓️ 30 September 2019

⏱️ 9 minutes

🧾️ Download transcript

Summary

Transcript

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0:00.0

So by this episode, you may be coming just a little bit more comfortable with inflammatory

0:05.6

anemia. And again, it's important to rule out the other stuff. So you've got to be sure that

0:11.9

there's not an iron deficiency state, but we'll get back to that a little bit. Of course,

0:16.5

you want to rule out things like B-12 deficiency, folate deficiency, hemolytic anemia.

0:23.4

You want to be pretty sure you're not dealing with a bone marrow disease process or an

0:27.5

aplastic anemia and obviously not a genetic anemia like a sickle cell disease.

0:34.4

And that all being said, I think the challenge comes back to, it can be really difficult, at

0:39.8

least for me, to know if sometimes there's a combination of an iron deficiency anemia with

0:45.8

an inflammatory anemia. This is particularly true in inflammatory conditions where there is blood

0:52.1

loss. So inflammatory bowel diseases, for instance,

0:55.8

and others. I mean, back in the days before my time, bone marrow was used as a standard for

1:02.8

diagnosing iron deficiency. So if you lacked iron in the bone marrow, that showed you did not

1:09.3

have adequate iron stores. But we don't go to that

1:13.2

for iron deficiency anemia, and we rarely go to it in inflammatory anemia diagnosis. It's invasive,

1:21.0

it hurts, it can be subject to misinterpretation with the wrong pathologist, and I can't even imagine the cost of trying to

1:29.8

diagnose inflammatory anemia with a bunch of bone barrels because we're talking about a lot,

1:36.1

a lot of people that have this very common problem. So what labs can we look at? Well,

1:41.9

I already mentioned in the last episode, serum ferritin.

1:45.6

If it's very high, there is an inflammatory state.

1:48.8

Now, that does not rule out iron deficiency anemia.

1:51.7

But the corollary to that is when you have a very low ferretin,

1:55.5

and I would go back to my iron deficiency anemia lectures,

...

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