Alzheimer’s Isn’t Inevitable: What Science Says You Can Control Starting Now | EP 385
DR. GUNDRY PODCAST: GUT HEALTH, WEIGHT LOSS, AND NUTRITION
PodcastOne
4.6 • 1.8K Ratings
🗓️ 6 January 2026
⏱️ 34 minutes
🧾️ Download transcript
Summary
In this episode, I sit down with Dr. Lisa Mosconi, director of the Women’s Brain Initiative at Weill Cornell Medical College, to challenge one of the most deeply ingrained assumptions in brain health: that Alzheimer’s is largely out of our control.
If you’ve ever felt like Alzheimer’s risk is something you can only react to later in life, this conversation may completely change how you think about your brain—and what you can do to protect it now.
For full show notes and transcript: https://drgundry.com/lisa-mosconi-alzheimers-prevention
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Transcript
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| 0:00.0 | Welcome to the Dr. Gundry podcast, where Dr. Stephen Gundry shares his groundbreaking research from over 25 years of treating patients with diet and lifestyle changes alone. |
| 0:11.1 | Dr. Gundry and other wellness experts offer inspiring stories, the latest scientific advancements and practical tips to empower you to take control of your health and live a long happy life. |
| 0:24.2 | Most people, I think the general public assumes that men get dementia more than women. |
| 0:32.3 | But in fact, the opposite, like you say, is completely, you know, it's exactly the opposite. |
| 0:38.7 | It's exactly the opposite, |
| 0:44.8 | yeah. The vast majority of people who get dementia, Alzheimer's, are women. And you guys are so much healthier than us men. I mean, you would assume, right? And also what I think is really |
| 0:51.4 | interesting is that Alzheimer's disease, the only age-related |
| 0:55.0 | neurodegenerative condition that affects more women than men, like Parkinson's, more men, |
| 1:01.0 | vascular dementia of 50-50. So there seems to be something specific to women that increases |
| 1:07.0 | risk of Alzheimer's. So what is it about women's brains that are so unique that this |
| 1:16.2 | seems to be a problem more for women than for men? Yes, there are many things that make women's |
| 1:23.2 | brains really unique. And I think a big determining factor is really hormonal health, |
| 1:29.4 | because I think it's very helpful to think of brain health as impacted by a number of factors. |
| 1:37.0 | Like you have your genes, you have your DNA, you have a lifestyle, you have your medical |
| 1:41.2 | health, you have your environment, you have your hormone. |
| 1:51.5 | And all these factors really act synergistically to determine a person's risk of Alzheimer's. |
| 1:54.5 | But at the same time, a person comes with allies. |
| 1:59.5 | You know, there are things that reduce your risk and other factors that can increase your risk, the apolypolypolyrotein E, the APOE4G, and you mentioned before. |
| 2:04.0 | And hormones are actually incredibly powerful allies that protect you against Alzheimer's and brain aging at large. |
| 2:13.8 | The difference is that men have a lot more androgens like testosterone. |
| 2:19.4 | Women have a lot more estrogens like estradiol. |
| 2:23.4 | All these hormones are very powerful. |
... |
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