Hey, all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Derek Christensen.

Thank you so much for listening today. Go check out real life pharmacology.com. We've got a free 31-page

PDF on the top 200 drugs. It's a great study guide. Absolutely doesn't cost you a thing except for an email.

So definitely go take advantage of that at realafarmacology.com.

All right. The drug the day today is Alfuzocin. Brand name of this medication is

Euroxetrol. And this medication is an alpha-1 blocker. And if you remember from previous episode, quite a while

ago, I did cover Tamselosin, and I have covered, I believe, a couple of the non-selective alpha

blockers as well. So, alfuzocin tends to be more on the selective side when it comes to alpha blockers.

So basically what that means from a clinical practice standpoint, we're going to be selective for the bladder tissue more so than the blood vessels.

So non-selective alpha blockers affect the vessels and bladder tissue,

and that can lead to significant risk for dizziness and hypotension.

Now, it can happen with the selective agents as well,

but the risk is generally considered less with a medication

like elphozosin. So this medication is used for BPH. That is absolutely the primary use that I've

seen it used in practice. There is an off-label use to potentially help with stones that are in the urator

and to help pass those stones out through the urine. Basically, it kind of opens up the passageways

to maybe help relieve some of that pressure and pain associated with that passage.

So those are the two uses that I've seen this medication used for.

It comes as an extended release tablet, 10 milligrams once a day.

And again, how that drug works mechanistically, it's an alpha-1 antagonist or blocker, and it works in the lower urinary tract

and essentially blocks sympathetic action.

And if you remember, that sympathetic action on those alpha receptors causes smooth muscle

...