Hey all, welcome back to the Real Life Pharmacology podcast. I am your host, Eric Christensen.

Thank you so much for taking the time to listen today. You can find me at reallife pharmacology.com,

also on LinkedIn as well. And of course, I want to remind you, go to real life pharmacology.com.

Take advantage of that top 200 study guide, 31 page PDF.

Absolutely free to you.

I highlight the most important clinical pearls from each of those top 200 drugs.

So absolutely must have a little resource there.

So today I'm going to cover a Lendronate,

which the brand name of that medication is Phosphamax.

This is from a class of medications used in the management of osteoporosis.

So being a bisphosphonate mechanistically, how this drug works is the drug

ultimately blocks the action of osteoclass. So if you go back to physiology and you remember osteoclast and osteoblast, the easiest way I remember it is osteoblast, build bone, and osteoclass break them down.

Okay?

So blast build, class, break them down.

Now, by inhibiting osteoclast, we're essentially inhibiting that

breakdown of the bone, sometimes called decreasing bone resorption. And that's going to ultimately

increase bone mineral density, which makes your bones stronger,

obviously, and helps fight off some of the negative aspects of osteoporosis. So that's how the

drug works. With administration, this is probably one of the most important patient education points.

And this is definitely what I see patients get tripped up on or forget about most often is how to administer the drug.

So remember these important points.

So 30 minutes before food, water, other medications, everything.

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