Adrenopause: the Decline of DHEA, Low Testosterone and Low Libido
High Intensity Health with Mike Mutzel, MS
Mike Mutzel
4.7 • 1.3K Ratings
🗓️ 29 May 2022
⏱️ 16 minutes
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Summary
Support your Circadian Rhythm and sleep with MYOXCIENCE's targeted adrenal support nutrients in the morning and evening:
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Link to video, research: https://bit.ly/3N0ZI8s
Time Stamps:
00:10 Adrenopause is when your adrenals go into a state of decline.
00:30 About 75% of estrogens and androgens come from adrenals in post-menopausal women.
01:00 Adrenopause can appear as low DHEA, low cortisol, low cortisol awakening response, and low libido.
01:40 The adrenal medulla is the innermost portion of the adrenal gland.
01:45 Adrenal glands make epinephrine and norepinephrine.
02:00 The zona reticularis and zona fasciculata are where cortisol and other corticosteroids are released.
02:50 Cortisol should be high in the morning and lower at night.
03:30 Atrophy of portions of the adrenal glands can lead to adrenopause, which is linked with sub-optimal testosterone, poor immunologic responses, aberrant changes in estrogen and vaginal dryness.
05:40 DHEA is metabolized into testosterone, dihydrotestosterone, and estrogen, as well as affect immunologic health, brain tissue and other aspects of physiology.
07:10 Men should test DHEA before considering HRT.
08:10 You can test serum DHEA sulfate, the storage form of DHEA.
08:50 The DUTCH plus complete tests your cortisol awakening response, DHEA, melatonin, estrogen metabolites and progesterone.
09:45 Supplement timing: You may supplement adrenal glandulars and thyroid extracts in the morning and DHEA in the evening.
11:10 General dosing: men – 10 mg/decade of life, women – 2.5mg/decade of life
11:45 Insulin resistance can increase levels of androgens with DHEA supplementation.
12:20 Exposure to morning sunlight and evening sunlight can stimulate your cortisol awakening response.
12:45 The amplitude and intensity of your circadian clock system becomes muted as you age.
Transcript
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| 0:00.0 | Hey friends welcome back. So I know you've heard about menopause and angiopause, but in today's |
| 0:04.0 | video we're going to talk about adrenopause. You're like adrenopause, Micah, are you over here |
| 0:08.7 | making stuff up? I am not making stuff up, I swear. This is what scientists have referred to |
| 0:13.5 | when the adrenals go into a state of decline. They, the androgens from the adrenal cortex here. |
| 0:19.6 | This is the adrenal gland. As you know, they sit sort of on top of the kidneys. You have two adrenal |
| 0:24.8 | glands. You go through adrenal pods and this is really, really important. I can't under-invacize |
| 0:31.0 | this enough for post-menopausal women because about 75% of the estrogens and the androgens |
| 0:37.9 | that are made for women especially after menopause come from the adrenals. So when the adrenals go |
| 0:44.6 | through this natural state of decline and this can vary based upon life load, based upon stressors, |
| 0:50.8 | perceive the natural stressors, travel schedules, disease states, overall metabolic health. |
| 0:57.2 | This can, I've seen individuals in their 20s that have futures of adrenopause, meaning that they |
| 1:03.2 | have low DHA. They have low cortisol. They have a really low cortisol awakening response. They are |
| 1:08.7 | looking tired. They cannot hang on to muscle. They don't have libido or sex drive. They're |
| 1:13.6 | hairs falling out. All these things can be linked to this. Now we're going to talk a little bit more |
| 1:17.6 | about it. I think it's just something that you should put on your radar. We're going to talk about |
| 1:21.1 | some blood tests that you should be aware of, especially for men over 40 and women who have been |
| 1:26.4 | through menopause. Let's talk a little bit more about the adrenal glands, some anatomy, |
| 1:31.0 | some of the structures here, and where the different hormones are made and some things you should know |
| 1:35.6 | about, okay? So you have within the cortex, let's first talk about the adrenal medulla. This is the |
| 1:41.2 | most inner portion of the adrenal gland. This is where your catacole means part of which your catacole |
| 1:47.5 | are also released in the brain, but the adrenal glands make noripinephrine and epinephrine, |
| 1:53.2 | also known as adrenaline and noradrenaline. That's the inner most portion of the adrenal medulla. |
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