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The Quanta Podcast

A Newfound Source of Cellular Order in the Chemistry of Life

The Quanta Podcast

Quanta Magazine

Life Sciences, Science, Physics

4.7638 Ratings

🗓️ 1 April 2021

⏱️ 28 minutes

🧾️ Download transcript

Summary

Inside cells, droplets of biomolecules called condensates merge, divide and dissolve. Their dance may regulate vital processes.

The post A Newfound Source of Cellular Order in the Chemistry of Life first appeared on Quanta Magazine

Transcript

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0:00.0

Welcome to Quantum Magazine's podcast.

0:07.0

Each episode we bring you stories about developments in science and mathematics.

0:12.0

I'm Susan Vallett.

0:14.0

Imagine packing all of the people in the world into the Great Salt Lake in Utah.

0:19.0

We're all jammed shoulder to shoulder, but we've got superpowers and charged past each other

0:25.3

at insanely high speeds.

0:27.6

That gives you an idea of how densely crowded it is in a typical cell filled with 5 billion

0:33.7

proteins, and new discoveries are shedding light on how those cells work. That's next.

0:41.7

While you're listening to podcasts, remember to check out the other Quantum Magazine podcast,

0:47.2

The Joy of X. Host Steven Strogatz interviews top-tier scientists and mathematicians. New

0:54.1

episodes out now.

0:55.5

Also, tell your friends about this podcast and give us a like or follow where you listen.

1:01.0

It helps people find the Quantum Magazine podcast.

1:07.0

In a busy cell, enzymes need to find their substrates, and signaling molecules need to find their

1:14.0

receptors. This allows the cell to carry out the work of growing, dividing, and surviving.

1:20.9

If cells were sloshing bags of evenly mixed cytoplasm, that would be hard to do, but they're not. Membrane-bounded organelles

1:30.7

help to organize some of the contents. They compartmentalize sets of materials and provide

1:36.8

surfaces that enable important processes like the production of ATP, the biochemical fuel of cells,

1:46.7

but they're only one source of order.

1:54.1

Recent experiments reveal that some proteins spontaneously gather into transient assemblies called condensates. It's a response to molecular forces that balance transitions between

2:00.7

the formation and dissolution of droplets

2:03.4

inside the cell. Condensates are sometimes referred to as membrane-less organelles. They can sequester

...

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