A Deep Dive Into the Understanding of Type 1 Diabetes with Emily Sims
Finding Genius Podcast
Richard Jacobs
4.4 • 1K Ratings
🗓️ 7 December 2020
⏱️ 41 minutes
🔗️ Recording | iTunes | RSS
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Summary
By the time a person presents with clinical diabetes, about 80 percent of their beta cells—the cells that produce insulin—have been destroyed. Could a better understanding of these cells lead to earlier intervention and more effective treatment for diabetes?
Tune in to learn:
- What the main functions are of the pancreas, and what goes wrong in diabetes mellitus
- How immature insulin differs from mature insulin, and how this relates to type 1 diabetes
- How better treatment—or even a cure—for diabetes may be possible with a better understanding of beta cell health and the role of beta cells in the progression of disease
Physician-scientist, Emily Sims, is an assistant professor of pediatrics at Indiana University who focuses on the study of endocrinology and clinical and translational research on type 1 diabetes mellitus. Specifically, her lab is researching how pancreatic beta cells contribute to the development of type 1 diabetes, and whether there is a way to cure rather than just treat the disease.
Sims provides insight on the disparities between what she sees in the clinic versus the research lab. She shares what's been discovered through research using the Network for Pancreatic Organ Donors with Diabetes (nPOD) depository, for instance, how type 1 diabetes pathology differs in young children versus adults. She also discusses what beta cell dedifferentiation means, and how it could be considered a new form of beta cell failure in type 1 diabetes.
Visit https://www.trialnet.org/ to learn more about current developments and discoveries in the world of diabetes research.
Available on Apple Podcasts: apple.co/2Os0myK
Transcript
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| 0:00.0 | Forget frequently asked questions common sense common knowledge or Google how about advice from a real genius |
| 0:06.8 | 95% of people in any profession are good enough to be qualified and licensed 5% go and beyond. They become very good at what they do. |
| 0:15.0 | But only 0.1% are real Jesus. |
| 0:18.3 | Richard Jacobs has made it his life's mission to find them for you. |
| 0:22.4 | He hunts down and interviews geniuses in every |
| 0:24.7 | field, sleep science, cancer, stem cells, ketogenic diets and more. Here come the geniuses. |
| 0:30.1 | This is the Finding Genius Podcast. |
| 0:33.0 | That is Richard Jacobs. |
| 0:35.0 | Hello, this is Richard Jacobs with the Finding Genius Podcast. |
| 0:41.0 | I have Emily K Sims. |
| 0:43.2 | She's an assistant professor of Pediatrics |
| 0:45.1 | at Indiana University, and she's looking at issues |
| 0:49.1 | surrounding pediatric endocrinology. |
| 0:51.2 | So Emily, thanks for coming. Thanks, I'm excited to be here. Good, well tell me about your work. What's what's involved? Yeah, so like you said, I'm a physician scientist, so I'm a pediatric end chronologist is the physician part. So I see patients, |
| 1:05.7 | pediatric patients, so kids with hormone problems and diabetes, specifically. And then my research is focused on diabetes. |
| 1:14.5 | So I have a lab that does very basic science research and I also do clinical |
| 1:20.6 | and translational research that kind of is mostly focused on the beta cell and diabetes. |
| 1:26.2 | So you know you have a pancreas and your pancreas has these cells called beta cells that make insulin and |
| 1:31.7 | basically all forms of diabetes, |
| 1:34.0 | beta cells don't make insulin like they're supposed to. |
| 1:36.8 | And so because of that you have high blood sugars and you need to get treated. |
| 1:40.7 | And I tend to focus on type 1 diabetes and that's autoimmune disease. to get attacked by your immune |
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