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Next Question with Katie Couric

A CAR T Revolution: Allogene is Bringing Lifesaving Cancer Treatment to More Patients

Next Question with Katie Couric

Katie Couric Media

News, Health, Society & Culture, Commentary, Documentary,, Health & Fitness

4.44.7K Ratings

🗓️ 24 November 2025

⏱️ 54 minutes

🧾️ Download transcript

Summary

CAR T therapy has delivered remarkable results for people with certain blood cancers—sometimes sending aggressive disease into deep remission after a single infusion. But today, only about 20% of eligible patients can actually get it. In this episode, sponsored by our partners at Allogene Therapeutics, Katie sits down with Dr. Zachary Roberts to unpack why access remains so limited and how new allogeneic (or “off-the-shelf”) CAR T therapies could be a turning point. They discuss how using healthy donor T-cells, rather than a patient's own, may help bypass manufacturing hurdles and bring advanced treatment to more oncologists, more hospitals, and more communities. To learn more, visit Alpha3trial.com. #AllogenePartner

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Transcript

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0:00.0

This episode is brought to you by Allogene, a company redefining how we fight cancer and autoimmune disease.

0:07.3

By pushing the boundaries of Cartyce cell therapy, Allogene is creating next generation off-the-shelf treatments designed to reach more people.

0:17.2

Learn more at Allogene.com.

0:23.6

Hi, everyone.

0:25.3

Cancer treatment has come such a long way from the blunt tools of chemo to today's precision

0:30.2

immunotherapies like CAR-T or chimeric antigen receptor T-cell therapy.

0:35.9

Our partner, Allogene Therapeutics, is helping lead that transformation.

0:40.7

Carty is amazing. It reprograms your own immune cells to find and destroy cancer. And because it's

0:47.7

targeted, it does it without some of the most brutal side effects of, say, chemotherapy. But access has been a real challenge.

0:55.4

That's where Allogene comes in, developing truly off-the-shelf, card tea treatments, made from

1:01.5

healthy donor cells, and ready when patients need them most. Who better to understand these

1:07.5

exciting developments than Allogene's chief medical officer, Dr. Zach Roberts.

1:12.8

We talked about how cancer outsmart some of its fiercest opponents, but how CAR-T therapy is changing

1:19.9

the face of the disease. But first, I wanted to know what drew him to cancer research in the first

1:25.7

place. Dr. Zachary Roberts, so nice to meet you. I admire people like you so much who are

1:34.3

cancer scientists, who are trying to come up with better treatments to save people's lives

1:41.3

or to at least manage their disease. I'm curious, how did you get interested in

1:46.9

cancer research? And by the way, thank you that I appreciate that you did. Well, thanks, Katie.

1:52.2

This is absolutely lovely to be here with you today. I have to say that I was interested from a very, very

1:58.0

young age. I grew up wanting to be a scientist, wanting to be a doctor.

2:04.2

I became quite fascinated with how cells kind of went wrong. They're a normal cell one day,

2:10.9

and then they're a cancer cell the next. And so really understanding what genes were in play,

...

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