974 - SIBO & Histamine Intolerance

Dr. Ruscio Radio, DC: Health, Nutrition and Functional Healthcare

Dr. Michael Ruscio, DC

Medical, Health, Functionalmedicine, Alternative Health, Health & Fitness

4.5 • 774 Ratings

🗓️ 7 July 2025

⏱️ 55 minutes

🔗️ Recording | iTunes | RSS

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Summary

Today I’m happy to chat with our patient Leslie who shares her successful journey with histamine intolerance healing. We’ll go through how SIBO led to her histamine issues, the connection to low vagus nerve tone, as well as the low histamine diet and treatments such as dao enzymes. Tune in to learn how you can reduce histamine in the body naturally.

Start healing with us! Learn more about our virtual clinic: https://drruscio.com/virtual-clinic/

Histamine Intolerance and Diet Guide: https://drruscio.com/guides/get-histamine-intolerance-guide/

💊 Products used in Leslie’s protocol:

✅Quercetin:

🔹3 capsules, 1-3 times per day.

https://store.drruscio.com/products/quercetin?variant=39556224778437

✅Resveratrol 500mg Ultra High Potency:

🔹1 capsule twice daily, may increase to 2 capsules twice daily

https://store.drruscio.com/products/resveratrol?variant=39555978494149

✅Vitamin C with Bioflavonoids :

🔹1-2 tsp or 2 capsules, 1-3x per day

https://store.drruscio.com/products/vitamin-c?variant=39591130595525

✅Histamine Digest (DAO enzyme):

🔹1 prior to meals, may increase to 2 prior to meals

https://store.drruscio.com/products/histamine-digest?variant=42174647435461

✅Intestinal Support Formula (ISF):

🔹5 grams of Immunoglobulin per serving

🔹Dose range: 5-10 grams per day. 2 scoops = 5 grams.

🔹May be taken with or without food.

🔹Research shows between 5-10 grams per day to be beneficial

https://store.drruscio.com/products/intestinal-support?variant=29051287765044

https://pubmed.ncbi.nlm.nih.gov/24833942/

✅Probiotic Triple Therapy Sticks:

🔹62 billion CFU per serving

🔹Dose range: 1-3 packets per day

🔹Probiotics may be taken with or without food

https://store.drruscio.com/products/triple-therapy-probiotic?variant=40164201922757

✅Vagus Nerve Stimulation with VaguStim

🔹15-30 minutes 1-2x per day

🔹Follow the user manual and app instructions to get started.

🔹It’s important to ensure you’re using enough conductive gel in the ears for the device to work effectively. If you’re only noticing a faint sensation, even with the device setting fairly high, you’re either not using enough gel or the batteries are low.

🔹It may take up to 1-2 months to observe a benefit from vagus nerve stimulation

https://vagustim.io/collections/home/products/vagus-nerve-stimulation-vns-device-for-individuals

🧠Check out our video on vagus nerve stimulation for more information

4 Powerful Vagus Nerve Tools to Rewire Your Nervous System:

https://www.youtube.com/watch?v=Adccokcgo0U

👇 Watch more videos like this 👇

➡️5 Warning Signs You’re Histamine Intolerant:

https://www.youtube.com/watch?v=JPBAd9RzIf4

➡️The Top Diet & Supplements For Healing Histamine Intolerance:

https://www.youtube.com/watch?v=stRThUfzfMM

Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1

And if you have any questions or topics you would like covered, let me know in the comments!

👇Read these next 👇

➡️Vagus Nerve Damage Symptoms, & How to Deal with Them:

https://drruscio.com/vagus-nerve-damage-symptoms/

➡️Everything You Need To Know About Histamine Intolerance:

https://drruscio.com/everything-you-need-to-know-about-histamine-intolerance/

Timestamps

00:00 Intro

02:45 SIBO & histamine intolerance signs

07:30 Histamine intolerance protocol

10:57 Low histamine diet

16:14 How intolerance happens

18:24 Gut-brain connection

23:32 Probiotics

25:26 Vagus nerve stimulation

36:21 The importance of mindset

40:31 Key takeaways

41: 17 Choosing the right healthcare

Featured Studies

📉Low Serum Diamine Oxidase Activity & Carbohydrate Malabsorption:

https://pubmed.ncbi.nlm.nih.gov/28042564/

📉Disorders of gut-brain interaction in the US:

https://pubmed.ncbi.nlm.nih.gov/36961084/

📉Probiotics for Allergic Rhinitis: https://pubmed.ncbi.nlm.nih.gov/35663980/

📉Symptoms and psychological status in IBS: https://pubmed.ncbi.nlm.nih.gov/36178333/

📉Vagus nerve stimulation & histamine-induced itching: https://pubmed.ncbi.nlm.nih.gov/12105316/

📉Limbic & temporal brain structures & mood enhancing by vagus nerve stimulation: https://pubmed.ncbi.nlm.nih.gov/17564758/

📉Transcutaneous Auricular Vagus Nerve Stimulation in IBS-C: https://pubmed.ncbi.nlm.nih.gov/39689011/

📉Serum-derived bovine immunoglobulin protein isolate in IBS-D https://pubmed.ncbi.nlm.nih.gov/24833942/

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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.

Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g

*Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.

Transcript

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0:00.0	Welcome to Dr. Rucho Radio, providing practical and science-based solutions to feeling your best.
0:14.8	To stay up to date on the latest topics, as well as all of our prior episodes, make sure to subscribe in your podcast player.
0:22.2	For weekly updates, visit Dr.ruciot.com.
0:25.6	If you've been treated for SIBO, without full response, it's possible that two fairly common factors are also present.
0:34.4	Histamine intolerance and disordered gut-brain interaction or said another way,
0:39.9	low tone or function of the vagus nerve. Now, here are two data points that support this.
0:49.0	Firstly, Canadian Journal of Gastroenterology and Hepatology 2016, finding that 30 to 55% of patients with
0:59.5	chronic digestive symptoms have underlying histamine intolerance.
1:05.1	Second data point, a 2023 review paper finding that approximately four out of every 10 adults has disordered
1:15.0	gut-brain interaction, and this is said another way, as low tone or function in the vaguest nerve.
1:24.4	Today, what I'd like to do is share a little more detail on these two factors and what you can do about them through a case study from Leslie, a patient from the clinic, and how she was able to improve bloating, hives, anxiety, fatigue, and sleep, amongst a few other symptoms.
1:48.9	And if you're new here, welcome. I am Michael Rucho, a doctor in clinical practice, a adjunct
1:54.5	professor, and I also work as a clinical researcher with a few papers published in
1:59.0	scientific journals and more in the works. Let's go to the
2:03.2	conversation now with Leslie. Well, good morning, Leslie. Welcome. Hi, Dr. Roushio. Good to see you.
2:11.4	It's great to see you. It's great to be here with you on the other side of the clinical process where we have a victory to declare?
2:19.1	Yeah, I agree. I'm having some success, so I'm happy about that.
2:27.9	And we were talking before that with these sort of case studies, one of the main things we're
2:32.9	trying to achieve is teaching people
2:35.7	the main takeaways. And so in this case, the two things, and of course, in every individual,
2:42.6	there's always a lot of nuance also, but I think there's two kind of meta concepts, which were
2:48.6	overlooked histamine intolerance, and then some dysfunction between the gut
	...

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