4.5 • 774 Ratings
🗓️ 31 March 2025
⏱️ 57 minutes
🧾️ Download transcript
I’m excited to have Dr. David Perlmutter back on the podcast to discuss uric acid and its pivotal connection to our overall health. Which foods lower and raise uric acid? What is its role in diabetes, alzheimer’s, gut health, and brain health? All of this will be covered, as well as best protocols for lowering high uric acid. You don’t want to miss this! Listen now!
Learn more about lowering uric acid in Dr. Perlmutter’s book, Drop Acid!
https://drperlmutter.com/learn/books/
Connect with Dr. Perlmutter online:
https://www.instagram.com/davidperlmutter/
Need help navigating your digestive or other health conditions? Learn more about our virtual clinic: https://drruscio.com/virtual-clinic/
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00:00 Intro
01:30 Why uric acid is pivotal to health
05:57 Evolutionary origins of high uric acid
07:12 Why fructose is a major factor
13:10 What elevates uric acid?
18:47 How to monitor levels
24:22 Foods that raise vs. lower UA
25:43 Relation to diabetes & other diseases
29:40 Probiotic protocol to lower UA
31:39 Connection to gut health
35:59 Connection to brain health
44:10 New therapeutics to explore
52:49 How to lower uric acid
57:37 Final takeaways
📉Safety and efficacy of probiotic supplementation in 8 types of inflammatory arthritis:
https://pubmed.ncbi.nlm.nih.gov/36217542/
📉Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?: https://pubmed.ncbi.nlm.nih.gov/36774227/
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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g
*Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.
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0:00.0 | Welcome to Dr. Rucho Radio, providing practical and science-based solutions to feeling your best. |
0:14.8 | To stay up to date on the latest topics, as well as all of our prior episodes, make sure to subscribe in your podcast player. For weekly updates, |
0:23.2 | visit Dr. Rucho.com. Dr. David Prolmander, welcome back to the show. Well, I'm Michael. Great |
0:29.3 | to see you. I'm delighted to be back. It's been a while. You've been a busy bee, and |
0:34.0 | Uric acid is one of the things on your radar. So I'm excited to discuss more about this topic. |
0:39.5 | And like I was saying a moment ago, |
0:41.4 | pretty timely with my father, |
0:43.3 | recently having some gout, some high uric acid. |
0:45.9 | So a lot of this, I'm motivated to help inform his decisions |
0:51.3 | with our conversation. |
0:54.0 | That's true. |
0:55.3 | You know, we tend to pigeonhole things that we learn in our medical training in terms of |
1:01.5 | what they do in the body. |
1:03.0 | Like we say testosterone is a male hormone and progesterone is, you know, a female hormone |
1:09.9 | that is progestational and that's all we want to, you know, |
1:13.3 | we don't want to expand on things. And to think that uric acid, which we really identified |
1:18.4 | through our training as being the mediator of gout or not gout, and that's the end of it. |
1:24.8 | I've learned my lesson. Let's move on to the next topic. |
1:34.4 | It oftentimes is a little bit challenging to us to recognize that these chemicals in our bodies do a multitude of different things, uric acid not being any different. And then, you know, |
1:40.2 | the idea that we have recognized for decades that uric acid seems to be related |
1:46.8 | to metabolic issues, but now we are understanding that mechanistically it's actually causing |
1:54.0 | some of these metabolic issues. And so therefore, you know, with metabolic issues being so |
... |
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