We know from looking at muscle biopsy studies in human beings that when somebody gets off their bottom and stands up, it only takes less than two minutes, in fact, for the gene regulators to adapt at the muscular level,

and the cellular components that influence how insulin is handled change.

So within two minutes of getting off your bottom, at a fundamental cellular level, your body is changing.

And to me, that is like absolutely fascinating. Hello and welcome to Sigma Nutrition Radio.

I am your host, Danny Lennon, and we are here at episode 95.

And as some of you may have heard me mention before,

I'm a massive fan of standing workstations or standing desks.

And over the past couple of years, I've had a standing desk.

And then only recently, about five or six weeks ago,

I took it up a notch and went for the treadmill desk that I'd seen

talked about and I'd been looking into this for quite a while and decided to go for it.

And granted, it does look a bit weird, especially for people when they see it at first glance

and don't understand what I'm doing with this treadmill and this standing workstation.

But it's not just because I'm completely gone crazy.

There is actual science behind this and some very good reasons for trying to get on your feet

and be moving a bit more, especially if you're in a situation where you're going to have

chronic periods of time where you're sitting down,

which was going to be me if I didn't have a standing desk because of the amount of time I was spending on a laptop working.

So on today's show, I've got probably one of the most eminent researchers in the field of obesity,

especially when you look at areas like activity levels

and non-exercise activity with thermogenesis and the harms of sitting and how that plays into the

development of obesity and chronic disease risk. And that's Dr. James Levine, who is the professor

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