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Nature Podcast

9 November 2017: Axolotls & treating a genetic skin condition

Nature Podcast

podcast@nature.com

Science, Technology, News

4.5893 Ratings

🗓️ 8 November 2017

⏱️ 24 minutes

🧾️ Download transcript

Summary

This week, a potential stem cell treatment for a genetic skin condition, and the disappearing axolotl. 

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Transcript

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0:00.0

Nature.

0:02.0

In a experiment, I don't know yet.

0:06.0

Why is Blight so far?

0:08.0

Like, it sounds so simple.

0:09.0

They had no idea.

0:11.0

But now the data's people.

0:12.0

I find this not only refreshing, but at some level astounding.

0:20.0

Nature. Nature.

0:26.1

Welcome back to the Nature podcast.

0:31.5

This week we're looking at using transgenic stem cells to regenerate an entire epidermis.

0:35.3

Plus, we'll be looking at the unexpected disappearance of the axolotl.

0:38.7

This is the nature podcast for November the 9th, 2017.

0:41.5

I'm Benjamin Thompson and I'm Charmne Bundell.

0:50.4

Well, I'm up first this week, talking about a new paper that details the use of transgenic stem cells to treat a condition called junctional epidermalysis bolosa, or J.E.B.

0:56.7

Now, J.E.B is a genetic condition that affects the skin, making it incredibly fragile,

1:02.2

with the top layer, the epidermis, failing to attach to the base layer, known as the dermis.

1:07.3

There are different severities of this condition, and some people experience chronic skin wounds

1:11.3

or blistering of their mucosal membranes. There is no cure for J.E.B., and these recurrent skin wounds

1:16.6

can lead to infections and a predisposition to skin cancer. 40% of children born with J.E.B.

1:24.5

I wanted to get a sense of what life is like for somebody with J.E.B.

1:28.1

So I spoke to Anne-Marie, whose daughter Tia has the condition and has had health issues

1:32.1

since the day she was born.

...

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