73. How High Cholesterol Can Be Healthy, and Low Cholesterol Could be Harmful, with Dave Feldman.

Paul Saladino MD podcast

Paul Saladino, MD

Medicine, Health & Fitness

4.8 • 2.7K Ratings

🗓️ 5 October 2020

⏱️ 111 minutes

🔗️ Recording | iTunes | RSS

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Summary

If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not, you’ve got some homework to do, and I think you’ll be amazed at what you find. Dave’s work can be found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.

He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.

Time Stamps:

0:08:46 Podcast Begins

0:14:21 The Bradford Hill Criteria

0:15:29 Context matters in lipids

0:19:44 Carnivore MD's Lipid Panel

0:30:15 Why LDL can't be the root cause of CVD

0:35:57 Testing the Lipid Hypothesis

0:41:20 Why you can't look at LDL in a vacuum

0:47:38 High-density lipoprotein as a protective factor against coronary heart disease The Framingham study - The Framingham Study https://www.amjmed.com/article/0002-9343(77)90874-9/pdf

0:49:19 Metabolic health is what really matters

0:52:01 Premature Atherosclerosis Associated With Monogenic Insulin Resistance https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&

0:54:19 LDL quality is what actually matters

1:00:39 What's the root cause of oxidized LDL?

1:06:20 Why most LDL lab tests are bonk!

1:07:41 Dave's latest experiment results

1:16:12 Summary of Dave's Energy Model

1:21:21 The body holds onto and reuses cholesterol.

1:24:28 The vital importance of ample cholesterol

1:25:40 Fasting Increases Serum Total Cholesterol, LDL Cholesterol and Apolipoprotein B in Healthy, Nonobese Humans https://academic.oup.com/jn/article/129/11/2005/4721856

1:26:19 Brown Bears (Ursus arctos) Seem Resistant to Atherosclerosis \xadDespite Highly Elevated Plasma Lipids during Hibernation and Active State https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439871/

1:28:40 Strong increase in hydroxy fatty acids derived from linoleic acid in human low-density lipoproteins of atherosclerotic patients

Transcript

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0:00.0	Welcome to the Fundamental Health Podcast. I'm your host, Dr. Paul Saladino. This podcast
0:11.2	is the result of my relentless search to understand and correct the roots of chronic
0:15.1	disease and illness. In this podcast, I will share with you everything I have learned
0:19.0	about how to live the most healthy and radical life possible. Thanks for joining me on this
0:23.4	journey.
0:26.9	What is up, you guys? Welcome to another week of the podcast. I'm so glad that you are
0:31.0	joining me here. If you get my weekly newsletter, which you can sign up for at heartandsoil.co,
0:38.3	you will know that I've been thinking a lot about the remembering. This has been on my mind
0:42.5	a ton recently. And it's basically the idea that as a human group of people, as a human
0:48.5	species, as a human community, there's an amnesia. And there is a forgetting, a mist. And
0:57.1	as a forgetting regarding how we are meant to live as humans, how we are supposed to eat,
1:01.3	how we are supposed to be in nature, the importance of wild places and bare feet on the ground,
1:06.8	and pausing to appreciate the beauty of a sunset or a breeze in the fall or spending
1:12.2	time with people that we care about in community, creativity, and play. I got interested in
1:17.9	this originally because of the carnivore diet and the idea that knows to tail eating of
1:23.7	animals is really part of this forgetting and a part of the remembering. We've forgotten
1:28.1	that knows to tail animal foods are how we thrive as humans. And we see this across all
1:34.3	of the indigenous cultures that have been studied. I've been reading a lot about the
1:36.9	hods recently. I really want to go to Tanzania to spend time with the hods in next year. But
1:43.4	everything I have read shows that when you ask one of the members of the Hods to tribe,
1:50.2	what is the best day of your life? They will invariably say the day that I killed the biggest
1:55.7	animal and fed the tribe, the day that we can feed our tribes, the most nourishing foods on the
	...

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