72. Are Excess Polyunsaturated Fats (PUFAs) to blame for the epidemic of Chronic Diseases? With Chris Knobbe, MD

Paul Saladino MD podcast

Paul Saladino, MD

Medicine, Health & Fitness

4.8 • 2.7K Ratings

🗓️ 28 September 2020

⏱️ 119 minutes

🔗️ Recording | iTunes | RSS

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Summary

Dr. Knobbe began his practice of ophthalmology in 1994, after completing his residency training at the University of Colorado Health Sciences Center, in Denver, Colorado, USA. He was certified by the American Board of Ophthalmology in 1997 and has remained board-certified since then.

Eye physician and surgeon, Chris A. Knobbe, MD, had been in practice nearly 20 years when, in 2013, he asked himself the question, “Could macular degeneration be a ‘Westernized disease’? Could AMD be a disease that is the result of a Westernized diet?” That question would forever change his life.

The hypothesis that Dr. Knobbe would proffer holds that macular degeneration, which is the leading cause of irreversible vision loss and blindness in developed nations, is not only preventable, but treatable in the early to moderate stages, with an ancestral diet.

Time stamps:

0:11:08 Podcast Begins

0:12:15 Chris Knobbe's Background

0:19:07 The History of macular degeneration and human diets

0:37:32 Chronic illness and obesity was once virtually nonexistent

0:48:41 When did PUFAs come onto the scene?

0:55:40 Increase in adipose tissue linoleic acid of US adults in the last half centuryhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642429/

0:57:18 Is olive oil healthy?

0:58:47 PUFA's are the cause of chronic illness

1:02:29 The best health advice anyone could give

1:09:35 Dietary Stearic Acid Leads to a Reduction of Visceral Adipose Tissue in Athymic Nude Micehttps://www.researchgate.net/publication/265650090_Dietary_Stearic_Acid_Leads_to_a_Reduction_of_Visceral_Adipose_Tissue_in_Athymic_Nude_Mice

1:14:41 Why you need animal fats

1:17:32 Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in micehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180905/

1:18:41 Beef tallow increases apoptosis and decreases aberrant crypt foci formation relative to soybean oil in rat colonhttps://pubmed.ncbi.nlm.nih.gov/15572298/

1:21:56 Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/

1:23:26 Fat and essential fatty acid in mammary carcinogenesishttps://academic.oup.com/ajcn/article-abstract/45/1/218/4694942?redirectedFrom=fulltext

Transcript

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0:00.0	Welcome to the Fundamental Health Podcast. I'm your host, Dr. Paul Saladino. This
0:10.6	podcast is the result of my relentless search to understand and correct the roots of chronic
0:15.1	disease and illness. In this podcast, I will share with you everything I have learned
0:18.9	about how to live the most healthy and radical life possible. Thanks for joining me on this
0:23.4	journey.
0:27.2	That is up you guys. Welcome to the remembering. If you've heard me talk about this recently,
0:33.6	it's something that's been on my mind a lot. The remembering is the best way that I've
0:39.2	personally been able to encapsulate, to summarize, to crystallize kind of the emotions that I've
0:47.0	had recently around. What we're all doing here, what we're all doing as we're looking for
0:52.8	an ancestral diet, what we're all doing as we're looking for an ancestral way of life. I really
0:57.6	believe that we are trying to remember that we are trying to shed the amnesia of the past,
1:02.8	shed the amnesia of the present 2020 and remember who we are as humans. It's much bigger than
1:11.2	a carnivore diet than a nose-to-tail carnivore diet than an animal-based diet, all of which
1:15.0	I think are optimal diets for humans, but only encapsulate, only really start to address
1:22.1	the dietary piece. As we all know, it's much bigger than the dietary piece. It's about remembering
1:27.2	who we are as humans so that we can live as well as possible during the short amount of time we have
1:34.5	on this earth. I recently got to spend a couple of days at White Oak Pastures, one of my favorite
1:40.2	farms, a regenerative farm in Georgia, and I was reminded at how beautiful regenerative agriculture
1:46.8	is. Being a part of an ecosystem, seeing animals graze properly with birds and seeing soil that is
1:53.1	healthy, it's really moving. It's part of the remembering, understanding how we interact with
1:58.6	the land, how best interact with the land in 2020, and how our ancestors would have interacted with
2:03.7	the land. Regenerative agriculture mimics these ancient ancestral ecosystems the way that we would
	...

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