7. Tommy Wood, MD, PhD. Should you worry about ApoE4 on a keto/carnivore diet and how to avoid Alzheimer’s disease
Paul Saladino MD podcast
Paul Saladino, MD
4.7 • 2.7K Ratings
🗓️ 13 August 2019
⏱️ 100 minutes
🧾️ Download transcript
Summary
Tommy Wood MD, PhD is an elite-level professional nerd who has coached world class athletes in a dozen sports. He has an undergraduate degree in biochemistry from the University of Cambridge, a medical degree from the University of Oxford, and a PhD in physiology and neuroscience from the University of Oslo. Tommy is a Research Assistant Professor at the University of Washington, a Research Scientist at the Institute for Human and Machine cognition, and is on the scientific advisory board of Hintsa Performance. He is also CSO (Chief Snake Officer) at the Costa Rican Center for Bro Research. Tommy lives in Seattle with his wife Elizabeth and their two goofy boxers. In his spare time he can usually be found cooking, reading, or lifting something heavy.
Time stamps
8:27 APOE4 Gene
11:37 Background on APO lipoproteins
15:00 APOC3
15:47 APO interference on LDL receptors
17
19:17 Insulin resistance and LDL residence time(reverse causation).
20:37 Metabolic Disease of the American Population.
22:07 David Foster Wallace, "This is Water"
24:18 Is Insulin Resistance driving LDL reten?
28:09 What is APOE doing in the periphery?
29:08 Immunologic functions of lipoproteins.
30:46 Are higher levels of LDL protective?
32:07 How higher total cholesterol predicts longevity in a "normal" person.
33:38 APOE and the brain.
34:47 Ketones as precursor for cholesterol synthesis.
35:27 Newborns and ketosis.
36:05 Glucose,ketones, and cholesterol.
37:12 Glial cells in the brain.
40:22 How the APOE genes differ.
44:57 Why are people told not to eat high saturated fat when they have the APOE4 gene?
47:37 Confusion around keto/carnivore diets raising total cholesterol
49:17 The Bolivian Tsimonae.
53:52 APOE and evolutionary history.
54:19 Evolutionary pressure and longevity.
56:02 Miki Ben-Dor's findings on longevity of our ancestors.
57:40 Why APOE4 is beneficial from an infection standpoint.
1:00:10 Difference between refined and unrefined saturated fat.
1:03:02 Liquid fats effect on the gut.
1:03:17 Statins.
1:04::54 COQ10 levels in carnivores.
1:07:02 Lipophilic statins.
1:08:40 Statins and Dementia.
1:09:14 Amyloid hypothesis of Alzheimer's.
1:14:22 Problems with western medical education.
1:15:13 How is the system broken?
1:16:17 Insulin Resistance and
Transcript
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| 0:00.0 | Welcome to the Fundamental Health Podcast. I'm your host, Dr. Paul Saladino. This podcast |
| 0:11.1 | is the result of my relentless search to understand and correct the roots of chronic |
| 0:15.1 | disease and illness. In this podcast, I will share with you everything I have learned |
| 0:18.9 | about how to live the most healthy and radical life possible. Thanks for joining me on this |
| 0:23.3 | journey. |
| 0:25.3 | What's shaking? I hope you are having an amazing day. My morning has been fantastic because |
| 0:35.4 | I haven't getting ready to release this podcast, which I am sure you will all be blown away |
| 0:42.2 | by. I had the opportunity recently to hang out with my buddy, Tommy Wood again hanging |
| 0:48.5 | out with Tommy Wood is like drinking from a fire hose. I always learned so much. I appreciate |
| 0:53.2 | him immensely. You guys know him from the previous episode in which we discussed all sorts |
| 1:00.2 | of wide-ranging things. You should refer to that one. The title of the podcast is The Blue |
| 1:05.5 | Zones Are A Myth. That's the original podcast that did with Tommy. Incidentally, since we |
| 1:10.4 | recorded that podcast, a new paper was published, which continued to substantiate the notion |
| 1:16.5 | that The Blue Zones Are In fact A Myth. Tommy texted me after we did this podcast and said, |
| 1:24.2 | I can't believe I didn't mention that paper in this podcast. I will talk more about that |
| 1:30.0 | paper. Soon, basically, that paper suggested that most of the Blue Zones are places where |
| 1:35.2 | people do not record their birth dates very well. Many of the ideas of super centenarians |
| 1:41.8 | may in fact be fraudulent. That is interesting, but that is in reference to the previous podcast. |
| 1:46.8 | This podcast, we just laid it down. Tommy just dropped bombs. I've had so many questions about |
| 1:54.0 | APOE4 in relation to Alzheimer's, in relation to the Amaloid hypothesis, in relation to ketogenic |
| 2:00.9 | and carnivore diets. As you will hear on this podcast, we really worked hard to delineate what |
| 2:07.6 | APOE4 is, what the different cells in the brain are, how this is connected with lipid metabolism, |
... |
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