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The Jesse Chappus Show

689: Methylene Blue, Fully Explained | Dr. Scott Sherr

The Jesse Chappus Show

Jesse Chappus

Nutrition, Health & Fitness, Alternative Health

4.61.6K Ratings

🗓️ 27 January 2026

⏱️ 120 minutes

🧾️ Download transcript

Summary

Dr. Scott Sherr is a Board Certified Internal Medicine Physician Certified in Hyperbaric Oxygen Therapy (HBOT) and Health Optimization Medicine (HOMe). He's a methylene blue expert.

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Show notes:

https://jessechappus.com/689

Transcript

Click on a timestamp to play from that location

0:00.0

Coming up on today's show.

0:02.0

94% of U.S. adults have mitochondrial dysfunction.

0:05.2

I see this on an everyday basis of my clinical practice, where we start low doses of methylene

0:09.7

blue and see fantastic benefit across the board, anything from pain, inflammation, brain fog,

0:15.8

mental health disorders, and all these other kinds of things, because it's all at the

0:19.6

edge base related to mitochondrial dysfunction.

0:21.7

The most common places to have this dysfunction are there on complex one or complex two.

0:26.5

In complex one and complex two of the complexes that are taking the electrons from your food

0:30.9

and bringing them to the electron transport chain so that you can make energy.

0:34.2

So if you don't have working complex one and complex two, you're not going to make energy effectively. You're not going to feel good. And so what

0:40.2

methane blue can do is it actually can compensate by bypassing some of those dysfunctional complexes

0:45.3

and allowing electrons to get further down the chain to be able to help you make energy. It also

0:49.0

can recycle and renew parts of those protein complexes and actually can help recycle and renew your NAD supply as well.

0:55.7

So insulin resistance is actually one of the major causes. The other major cause of a mitochondrial

0:59.3

dysfunction is the sympathetic spiral of doom. You also have toxins in the environment that

1:04.5

cause mitochondrial dysfunction directly, infections, medications. These are all causing significant

1:09.4

mitochondrial stress. And as a result of that, you're not making energy effectively.

1:12.6

It's one of those things where when you start taking it, you will realize that you probably

1:16.7

needed it all along.

1:19.8

Dr. Scott, my goal with you today is to create an in-depth masterclass on one of your

1:26.0

favorite compounds, methylene blue. Are you with me?

1:29.6

I'm with you. Let's do it, Jesse. Exciting. All right. Well, let's start out talking about what you're

...

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