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Freakonomics Radio

659. Can Marty Makary Fix the F.D.A.?

Freakonomics Radio

Freakonomics Radio + Stitcher

Documentary, Society & Culture

4.532.8K Ratings

🗓️ 16 January 2026

⏱️ 55 minutes

🧾️ Download transcript

Summary

It regulates 20 percent of the U.S. economy, and its commissioner has an aggressive agenda — faster drug approvals, healthier food, cures for diabetes and cancer. How much can he deliver? (Part two of “The Freakonomics Radio Guide to Getting Better.”)

Transcript

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0:00.0

When it comes to public health, the first year of the second Trump administration has been an unusually busy one and unusually controversial.

0:13.1

Most of this has run through Robert F. Kennedy, Jr., the Secretary of Health and Human Services.

0:18.0

In just the past few weeks, Kennedy overhauled the government's recommendations

0:22.0

for childhood vaccines and revised the so-called food pyramid, promoting animal proteins, especially,

0:28.8

while downgrading ultra-processed foods, refined carbohydrates, and added sugars. Kennedy's policies

0:35.3

affect several agencies under his purview, including the Food and Drug

0:39.2

Administration. The FDA has had a busy year of its own, approving new treatments for several

0:45.1

rare diseases, including cancers, as well as for rheumatoid arthritis and HIV. The agency also

0:51.9

approved a non-opioid pain medicine, the first of its kind in many years.

0:56.3

The next few years may be even busier. The FDA today is not going to be an FDA in a receive-only

1:04.9

mode. We're not going to be stingy librarians. We're going to go into the pipeline, find out what sounds promising, and bring that to the

1:13.2

forefront. That is Marty McCarrie, Commissioner of the FDA. He has been on Freakonomics Radio a few

1:19.7

times in the past, and he made a brief appearance in last week's episode about brain supplements.

1:25.3

McCarrie was a longtime surgical oncologist and professor of surgery at

1:29.5

Johns Hopkins University. He's also done a lot of health policy research. He's published hundreds

1:34.7

of papers and three books that critiqued the American health care system. Running the FDA is

1:41.2

McCarrie's first job in government, and he knows it's a big one.

1:45.6

The FDA regulates 20% of the U.S. economy, and there are so many aspects to the FDA,

1:52.7

and there are so many things broken at the FDA.

1:56.6

I spoke with McCarrie in October, but our release of this episode was delayed by the government shutdown.

2:02.6

What's interesting is just how timely the conversation feels right now.

2:06.4

It's always good to get an insider's view from an institution like the FDA.

...

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